Evidence map›Paper›PMID 10489936›Full record

ArticleDigestive diseases and sciences1999

Probiotic preparations dose-dependently increase net production rates of organic acids and decrease that of ammonia by pig cecal bacteria in batch culture.

T Sakata, T Kojima, M Fujieda, M Miyakozawa, M Takahashi, K Ushida

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Intake ofMicroorganisms · 2021
    Article
  5. Pitfalls in short-chain fatty acid research: A methodological review.Animal science journal = Nihon chikusan Gakkaiho · 2019
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

T SakataDepartment of Basic Sciences, Ishinomaki Senshu University, Ishinomaki, Japan.
T Kojima
M Fujieda
M Miyakozawa
M Takahashi
K Ushida
Ishinomaki Senshu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We tested probiotic preparations containing Bifidobacterium, Enterococcus, or Lactobacillus to see if they affect production of organic acids and ammonia by mixed cecal bacteria. Four preparations (Bibalance, Neorakuton, Yakult Seichoyaku, or Yakult Seichoyaku BL) were digested with HC and pancreatin before adding to batch cultures of 50% pig cecal contents. Concentrations of organic acids and ammonia in the culture were quantified. Two preparations stimulated the net production of short-chain fatty acids (SCFA) during the first 8 hr of incubation. From 8 to 24 hr of incubation, all preparations accelerated the net production of SCFA, succinic and lactic acids, and three preparations slowed the net production of isovaleric acid and ammonia, all dose-dependently. The above results indicate that the preparations tested accelerated the breakdown of hard-to-degrade carbohydrate(s) and, possibly thereby, decreased the breakdown of proteinous materials or increased bacterial cell body synthesis in a mixed culture of cecal bacteria.

Indexed as

Acetic AcidAcid-Base EquilibriumAmmoniaAnimalsBifidobacteriumButyric AcidCecumEnterococcusFatty Acids, VolatileHemiterpenesLactic AcidLactobacillusPentanoic AcidsProbioticsPropionatesSuccinic AcidAcetic AcidAmmoniaButyric AcidFatty Acids, VolatileHemiterpenesisovaleric acidLactic Acidn-pentanoic acidPentanoic AcidsPropionatespropionic acidSuccinic Acid

Identifiers

PMID10489936
OpenAlexW1571243005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.