ArticleDigestive diseases and sciences1999
Lactulose feeding in piglets: a model for persistent diarrhea and colitis induced by severe sugar malabsorption.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Bacteriocinogeny in experimental pigs treated with indomethacin and Escherichia coli Nissle.World journal of gastroenterology · 2011Article
- Cecal infusion of butyrate increases intestinal cell proliferation in piglets.The Journal of nutrition · 2007Article
- Increased colonic luminal synthesis of butyric acid is associated with lowered colonic cell proliferation in piglets.The Journal of nutrition · 2006Article
- Lactulose feeding lowers cecal densities of clostridia in piglets.JPEN. Journal of parenteral and enteral nutritionArticle
- Cecal infusion of butyrate does not alter cecal concentration of butyrate in piglets fed inulin.JPEN. Journal of parenteral and enteral nutritionArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We sought to determine, in a piglet model, whether severe sugar malabsorption causes colonic injury or inflammation. Twenty-four piglets were randomized to receive either control formula (CON) or CON supplemented with lactulose (LAC) (N = 12 each group). After seven days, inflammation, apoptosis, and crypt cell proliferation were assessed in the proximal colon (cecum). Lactulose feeding caused persistent diarrhea. In both groups, breath H2 concentration was low, suggesting no increased fermentation in the LAC group. Weight gain/volume formula intake was identical in the CON and LAC groups (0.09+/-0.13 and 0.09+/-0.11 g/ml) respectively. Injury to the colon did not occur, but inflammation of the colon (scale 0-5) was greater in LAC (score of 1.5+/-1.38) than in CON (0.42+/-0.79; P<0.05). Cell proliferation at the basal 40% of the crypt was 92% increased in CON (labeling index 22.8+/-9.9 vs. 11.9+/-2.8; P<0.05). We conclude that persistent feeding during severe sugar malabsorption permits weight gain but may cause colitis.
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Registered trials
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