ArticleDigestive diseases and sciences1999
Immunolocalization of transforming growth factor-alpha and epidermal growth factor receptor in the rat gastroduodenal area.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 30 citations in OpenAlex.
- Pathophysiology of Gastric NETs: Role of Gastrin and Menin.Current gastroenterology reports · 2017Review
- Neuroprotective effect of quercetin on the duodenum enteric nervous system of streptozotocin-induced diabetic rats.Digestive diseases and sciences · 2012Article
- EGFR is involved in control of gastric cell proliferation through activation of MAPK and Src signalling pathways in early-weaned rats.Cell proliferation · 2011Article
- Evaluation of mucosal damage and recovery in the gastrointestinal tract of rats by a penetration enhancer.Pharmaceutical research · 2008Article
- Effect of oral epidermal growth factor on mucosal healing in rats with duodenal ulcer.World journal of gastroenterology · 2003Article
- Transforming growth factor-alpha precursors in human colon carcinoma cells.Digestive diseases and sciences · 2001Article
- Veterinary nutraceutical medicine.The Canadian veterinary journal = La revue veterinaire canadienne · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The maintenance of gastrointestinal epithelium integrity requires a fine balance between proliferation and differentiation as well as protection against gastric acid secretion. Transforming growth factor-alpha (TGF-alpha) regulates these functions by binding to epidermal growth factor receptor (EGF-R). This study was designed to identify the localization of TGF-alpha and EGF-R in the rat gastroduodenal region. In the stomach, the surface and gastric pit cells showed staining for TGF-alpha antibodies in the cytoplasm and basolateral and apical membranes. TGF-alpha and EGF-R were observed in the supranuclear region of the cells lining the gland. In the duodenum, the enterocytes coexpressed both TGF-alpha and EGF-R in the supranuclear area. The EGF-R was also observed in the apical membrane. Brunner's glands were positive for both TGF-alpha and EGF-R antibodies. Our results demonstrate the coexpression of TGF-alpha and EGF-R in the rat gastroduodenal area, which suggests a functional role for them in the establishment and maintenance of the epithelial renewal.
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Registered trials
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