ArticleDigestive diseases and sciences1999
Characteristics of inflammation-induced hypertrophy of rat intestinal smooth muscle cell.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- A Potential Role of Cholinergic Dysfunction on Impaired Colon Motility in Experimental Intestinal Chagas Disease.Journal of neurogastroenterology and motility · 2022Article
- The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis.Nutrients · 2021Review
- Natural CAC chemopreventive agents from Ilex rotunda Thunb.Journal of natural medicines · 2019Article
- Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice.Nutrients · 2018Article
- Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation.Scientific reports · 2017Article
- Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn's disease and smooth muscle hypertrophy.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Mechanisms that mediate the development of fibrosis in patients with Crohn's disease.Inflammatory bowel diseases · 2014Review
- Inflammatory cytokines promote growth of intestinal smooth muscle cells by induced expression of PDGF-Rβ.Journal of cellular and molecular medicine · 2014Article
- Goblet cell hyperplasia and muscular layer thickening in the small intestine of a cynomolgus monkey.Journal of toxicologic pathology · 2010Article
- Endogenous IGF-I and alpha v beta3 integrin ligands regulate increased smooth muscle growth in TNBS-induced colitis.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Impaired acetylcholine-induced smooth muscle contraction in colitis involves altered calcium mobilization and AKT phosphorylation.Pflugers Archiv : European journal of physiology · 2008Article
- Article
- Persistent and selective effects of inflammation on smooth muscle cell contractility in rat colitis.Pflugers Archiv : European journal of physiology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation of the human intestine causes thickening of the smooth muscle layers, and studies in rats infected with Trichinella spiralis (Tsp) have shown hyperplasia of the intestinal smooth muscle cells (ISMC). We have shown that Tsp-induced inflammation caused a fivefold increase in total protein per ISMC over control, while ISMC from the noninflamed distal ileum also showed a threefold increase. The amount of alpha-smooth muscle (SM) actin per ISMC increased nearly 500% over control by postinfection (PI) day 6. The proportion of alpha-SM actin in the total cellular protein increased 200% by day 6 PI, indicating a higher density of alpha-SM actin in the hypertrophied ISMC. Gamma-SM actin mRNA increased sharply and was matched by an increased fractional content of gamma-SM actin protein. These increases in the smooth muscle-specific actins may affect force production and further demonstrate the plasticity of smooth muscle in the inflamed intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.