Trial reportClinical cardiology1999
Effects of acute alcohol infusion on duration and dispersion of QT interval in male patients with coronary artery disease and in healthy controls.
Trial report in Clinical cardiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- Cardiac reactivity during the ascending phase of acute intravenous alcohol exposure and association with subjective perceptions of intoxication in social drinkers.Alcoholism, clinical and experimental research · 2014Trial
- A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice.Communications biology · 2023Article
- QTc prolongation in adolescents with acute alcohol intoxication.European journal of pediatrics · 2022Observational
- Safety of prolonged treatment with bedaquiline in programmatic conditions.ERJ open research · 2022Article
- Consensus and Controversy in the Debate over the Biphasic Impact of Alcohol Consumption on the Cardiovascular System.Nutrients · 2021Review
- Sudden Unexpected Death and the Mammalian Dive Response: Catastrophic Failure of a Complex Tightly Coupled System.Frontiers in physiology · 2019Article
- Red Wine, Resveratrol and Atrial Fibrillation.Nutrients · 2017Review
- Unintentional drowning: Role of medicinal drugs and alcohol.BMC public health · 2017Article
- Acute effects of ethanol on action potential and intracellular Ca(2+) transient in cardiac ventricular cells: a simulation study.Medical & biological engineering & computing · 2016Article
- Citalopram-Induced Long QT Syndrome and the Mammalian Dive Reflex.Drug safety - case reports · 2015Article
- The anti-addiction drug ibogaine and the heart: a delicate relation.Molecules (Basel, Switzerland) · 2015Review
- Pharmacokinetic and pharmacodynamic drug interactions with ethanol (alcohol).Clinical pharmacokinetics · 2014Review
- Modifying effects of resting heart rate on the association of binge drinking with all-cause and cardiovascular mortality in older Korean men: the Kangwha Cohort Study.Journal of epidemiology · 2014Article
- Inappropriate ICD shocks caused by T-wave oversensing due to acute alcohol intoxication.Pacing and clinical electrophysiology : PACE · 2012Article
- Alcohol exposure and outcomes in trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2011Article
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- High-degree atrioventricular block in acute ethanol poisoning: a case report.Cases journal · 2009Article
- Ethanol for cardiac ischemia: the role of protein kinase c.Therapeutic advances in cardiovascular disease · 2008Review
- Alcohol ingestion influences the nocturnal cardio-respiratory activity in snoring and non-snoring males.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and hypothesisAlcohol consumption may have advantageous epidemiologic effects but ethanol also increases the risk of sudden coronary death. Prolongation of QT interval has been reported in chronic alcoholics. Long QT period predisposes to serious arrhythmias, and therefore we studied whether acute alcohol intoxication prolongs repolarization in patients with stable coronary artery disease (CAD).
methodsThe effects of acute ethanol steady-state intravenous infusion (0.72 g/kg body weight within 60 min) on QT interval and QT dispersion, assessed by 12-lead electrocardiograms (ECG), were studied in 22 men with stable CAD and in 10 controls. Heart rate variability was measured by Holter recordings.
resultsMean blood alcohol rose to 26.1 +/- 4.3 mmol/l(1.2 +/- 0.2/1000), and was maintained for 2 h. Heart rate was 56 +/- 7 beats/min before and 54 +/- 8 beats/min during ethanol infusion (NS). The heart rate-adjusted QT interval increased on the average 13-23 ms over the 12-lead ECG (p < 0.005). The QT dispersion remained unaltered. The was no difference in the repolarization response in the patients with CAD compared with the controls. The high- and low-frequency components of heart rate variability remained unaltered.
conclusionsIn middle aged men, regardless of the presence of CAD, moderate amounts of alcohol cause prolongation of ventricular repolarization. Changes in the activity of the autonomic nervous system do not seem to explain the observed phenomenon.
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