ArticleAmerican journal of human genetics1999
Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Osteoarthritis susceptibility loci defined by genome scan meta-analysis.Rheumatology international · 2006Pooled it
- Osteoarthritis susceptibility loci defined by genome scan meta-analysis.Rheumatology international · 2006Pooled it
- IL1R1 gene polymorphisms are associated with knee osteoarthritis risk in the Chinese Han population.Oncotarget · 2017Article
- Article
- Genetic influences on hand osteoarthritis in Finnish women--a replication study of candidate genes.PloS one · 2014Article
- Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.Osteoarthritis and cartilage · 2011Article
- Erosive osteoarthritis: a current review of a clinical challenge.Clinical rheumatology · 2010Review
- Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.BMC medical genetics · 2010Article
- Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.Arthritis and rheumatism · 2010Article
- Genetic dissection of granulomatous enterocolitis and arthritis in the intramural peptidoglycan-polysaccharide-treated rat model of IBD.Inflammatory bowel diseases · 2009Article
- Genetic polymorphisms of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86-bpVNTR) in susceptibility to knee osteoarthritis in a Chinese Han population.Rheumatology international · 2009Article
- Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study.Osteoarthritis and cartilage · 2008Article
- Common interleukin-6 promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis.Arthritis research & therapy · 2008Article
- [Pathogenesis of osteoarthritis--a snapshot].Zeitschrift fur Rheumatologie · 2007Review
- Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19.Annals of the rheumatic diseases · 2007Article
- Genome-wide search for microsatellite markers associated with radiologic alterations in the navicular bone of Hanoverian warmblood horses.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage.NMR in biomedicine · 2006Review
- Osteoarthritis linkage scan: more loci for the geneticists to investigate.Annals of the rheumatic diseases · 2006Article
- Linkage to nodal osteoarthritis: quantitative and qualitative analyses of data from a whole-genome screen identify trait-dependent susceptibility loci.Annals of the rheumatic diseases · 2006Article
- Cis- and trans-acting gene regulation is associated with osteoarthritis.American journal of human genetics · 2006Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
The genetic contribution to common forms of osteoarthritis (OA) is well established but poorly understood. We performed a genome scan, using 302 markers for loci predisposing to distal interphalangeal joint (DIP) OA. To minimize genetic heterogeneity in our study sample, we identified siblings with a severe, radiologically defined phenotype from the nationwide registers of Finland. In the initial genome scan, linkage analysis in 27 sibships gave a pairwise LOD score (Z) >1.00 with nine of the screening markers. In the second stage, additional markers and family members were genotyped in these chromosomal regions. On 2q12-q13, IL1R1 resulted in Z=2.34 at recombination fraction (theta) 0, allowing a dominant mode of inheritance. Association analysis of markers D2S2264, IL1R1, D2S373, and D2S1789 jointly provided some evidence for a shared haplotype among the affected individuals (P value of.012). Also, multipoint nonparametric linkage analysis yielded a P value of.0001 near the locus IL1R1 and P=.0007 approximately 20 cM telomeric near marker D2S1399, which, in two-point analysis, gave Z=1.48 (straight theta=. 02). This chromosomal region on 2q harbors the interleukin 1 gene cluster and, thus, represents a good candidate region for inflammatory and autoimmune disorders. Three additional chromosomal regions-4q26-q27, 7p15-p21, and Xcen-also provided some evidence for linkage, and further analyses would be justified to clarify their potential involvement in the genetic predisposition to DIP OA.
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