ArticleProceedings of the National Academy of Sciences of the United States of America1999
Chromatin remodeling directly activates V(D)J recombination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement.The Journal of experimental medicine · 2024Article
- Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.Nucleic acids research · 2020Article
- Control of V(D)J Recombination through Transcriptional Elongation and Changes in Locus Chromatin Structure and Nuclear Organization.Genetics research international · 2011Article
- Epigenetic control of recombination in the immune system.Seminars in immunology · 2010Review
- An activation-induced cytidine deaminase-independent mechanism of secondary VH gene rearrangement in preimmune human B cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Advances in immunology · 2008Review
- Article
- Chromatin accessibility and epigenetic modifications differ between frequently and infrequently rearranging VH genes.Molecular immunology · 2007Article
- B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.Nature immunology · 2004Article
- Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- A multistep mechanism for the activation of rearrangement in the immune system.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments.Genes & development · 2003Article
- Differential accessibility at the kappa chain locus plays a role in allelic exclusion.The EMBO journal · 2002Article
- Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Chromosomal integration of retinoic acid response elements prevents cooperative transcriptional activation by retinoic acid receptor and retinoid X receptor.Molecular and cellular biology · 2002Article
- V(D)J recombination becomes accessible.The Journal of experimental medicine · 2001Article
- Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination.The Journal of experimental medicine · 2000Article
- V(D)J recombination is not activated by demethylation of the kappa locus.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Postcleavage sequence specificity in V(D)J recombination.Molecular and cellular biology · 2000Article
- Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
V(D)J recombination substrate choice is regulated to ensure that the appropriate gene segments are rearranged during lymphocyte development. It has been proposed that regulation of substrate usage is determined by changes in accessibility of the DNA targets. We show that Rag-mediated recombination of an episomal substrate in cells is affected by its packaging into chromatin. Chromatinized substrates were inefficiently rearranged, and methylation further reduced recombination. Disruption of nucleosomes by using butyrate on methylated substrates was sufficient to activate recombination, and dexamethasone could activate recombination in the absence of detectable transcription. Therefore, chromatin structure, and its manipulation by altering nucleosome positioning, can directly affect recombination efficiencies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.