ArticleProceedings of the National Academy of Sciences of the United States of America1999
Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 129 citations in OpenAlex.
- Article
- In vivo functions of p75Trends in pharmacological sciences · 2021Review
- PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice.Cell death & disease · 2018Article
- Brain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration.Neural regeneration research · 2017Review
- Identification of Prdm genes in human corneal endothelium.Experimental eye research · 2017Article
- Up-regulation of HDAC4 is associated with Schwann cell proliferation after sciatic nerve crush.Neurochemical research · 2014Article
- The PR/SET domain zinc finger protein Prdm4 regulates gene expression in embryonic stem cells but plays a nonessential role in the developing mouse embryo.Molecular and cellular biology · 2013Article
- PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation.Biology · 2013Article
- Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation.The Journal of biological chemistry · 2012Article
- Nerve growth factor induces cell cycle arrest of astrocytes.Developmental neurobiology · 2012Article
- How histone deacetylases control myelination.Molecular neurobiology · 2011Review
- Nuclear localization of the p75 neurotrophin receptor intracellular domain.The Journal of biological chemistry · 2010Article
- Sall2 is a novel p75NTR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth.The EMBO journal · 2009Article
- Cardiovascular actions of neurotrophins.Physiological reviews · 2009Review
- Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor.PLoS biology · 2008Article
- p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- A Bex-cycle built for two.EMBO reports · 2006Review
- Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle.The EMBO journal · 2006Article
- Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A subclass of zinc finger proteins containing a unique protein motif called the positive regulatory (PR) domain has been described. The members include the PRDI-BF1/Blimp-1 protein, the Caenorhabditis elegans egl-43 and EVI1 gene products, and the retinoblastoma interacting protein RIZ. Here we describe a member of this family, SC-1, that exhibits several distinctive features. First, SC-1 interacts with the p75 neurotrophin receptor and is redistributed from the cytoplasm to the nucleus after nerve growth factor (NGF) treatment of transfected COS cells. The translocation of SC-1 to the nucleus was specific for p75, as NGF binding to the TrkA receptor did not lead to nuclear localization of SC-1. Thus, SC-1 provides a downstream transducer for the effects of NGF through the p75 neurotrophin receptor. Under normal growth conditions, SC-1 was found predominantly in the cytoplasm. On serum-starvation, SC-1 also translocated into the nucleus. A direct correlation between nuclear expression of SC-1 with the loss of BrdUrd incorporation was observed. These results imply that SC-1 may be involved in events associated with growth arrest.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.