ArticleProceedings of the National Academy of Sciences of the United States of America1999
Crosstalk between Galpha(i)- and Galpha(q)-coupled receptors is mediated by Gbetagamma exchange.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
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- Functional coupling of MEuropean archives of psychiatry and clinical neuroscience · 2020Article
- Group III metabotropic glutamate receptors regulate hypothalamic presympathetic neurons through opposing presynaptic and postsynaptic actions in hypertension.Neuropharmacology · 2020Article
- Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- βNature chemical biology · 2017Article
- Role of IGF1R(+) MSCs in modulating neuroplasticity via CXCR4 cross-interaction.Scientific reports · 2016Article
- G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide.British journal of pharmacology · 2012Article
- V1b and CRHR1 receptor heterodimerization mediates synergistic biological actions of vasopressin and CRH.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Gi-coupled γ-aminobutyric acid-B receptors cross-regulate phospholipase C and calcium in airway smooth muscle.American journal of respiratory cell and molecular biology · 2011Article
- The oligomeric state sets GABA(B) receptor signalling efficacy.The EMBO journal · 2011Article
- Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.The Journal of biological chemistry · 2011Article
- Synergistic activation of phospholipase C-beta3 by Galpha(q) and Gbetagamma describes a simple two-state coincidence detector.Current biology : CB · 2010Article
- Platelet function and Isoprostane biology. Should isoprostanes be the newest member of the orphan-ligand family?Journal of biomedical science · 2010Review
- Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration.The EMBO journal · 2009Article
- A dual receptor crosstalk model of G-protein-coupled signal transduction.PLoS computational biology · 2008Article
- Caveolin-1 alters Ca(2+) signal duration through specific interaction with the G alpha q family of G proteins.Journal of cell science · 2008Article
- Kinetics of G-protein-coupled receptor signals in intact cells.British journal of pharmacology · 2008Review
- Some G protein heterotrimers physically dissociate in living cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of Galpha(i)-coupled receptors often causes enhancement of the inositol phosphate signal triggered by Galpha(q)-coupled receptors. To investigate the mechanism of this synergistic receptor crosstalk, we studied the Galpha(i)-coupled adenosine A(1) and alpha(2C) adrenergic receptors and the Galpha(q)-coupled bradykinin B(2) and a UTP-preferring P2Y receptor. Stimulation of either Galpha(i)-coupled receptor expressed in COS cells increased the potency and the efficacy of inositol phosphate production by bradykinin or UTP. Likewise, overexpression of Gbeta(1)gamma(2) resulted in a similar increase in potency and efficacy of bradykinin or UTP. In contrast, these stimuli did not affect the potency of direct activators of Galpha(q); a truncated Gbeta(3) mutant had no effect on the receptor-generated signals whereas signals generated at the G-protein level were still enhanced. This suggests that the Gbetagamma-mediated signal enhancement occurs at the receptor level. Almost all possible combinations of Gbeta(1-3) with Ggamma(2-7) were equally effective in enhancing the signals of the B(2) and a UTP-preferring P2Y receptor, indicating a very broad specificity of this synergism. The enhancement of the bradykinin signal by (i) Galpha(i)-activating receptor ligands or (ii) cotransfection of Gbetagamma was suppressed when the B(2) receptor was replaced by a B(2)Gbeta(2) fusion protein. Gbetagamma enhanced the B(2) receptor-stimulated activation of G-proteins as determined by GTPgammaS-induced decrease in high affinity agonist binding and by B(2) receptor-enhanced [(35)S]GTPgammaS binding. These findings support the concept that Gbetagamma exchange between Galpha(i)- and Galpha(q)-coupled receptors mediates this type of receptor crosstalk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.