ArticlePlant physiology1999
Carbon and amino acids reciprocally modulate the expression of glutamine synthetase in Arabidopsis.
Article in Plant physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 220 citations in OpenAlex.
- Wheat glutamine synthetase TaGSr-4B is a candidate gene for a QTL of thousand grain weight on chromosome 4B.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Genome-Wide Identification, Phylogenetic and Expression Pattern Analysis of GATA Family Genes in Cucumber (Plants (Basel, Switzerland) · 2021Article
- Unravelling the Complex Interplay of Transcription Factors Orchestrating Seed Oil Content inInternational journal of molecular sciences · 2021Article
- Plastid ribosomal protein LPE2 is involved in photosynthesis and the response to C/N balance in Arabidopsis thaliana.Journal of integrative plant biology · 2020Article
- The GATA transcription factor GNC plays an important role in photosynthesis and growth in poplar.Journal of experimental botany · 2020Article
- Novel Aspects of Nitrate Regulation inFrontiers in plant science · 2020Review
- Rice OsLHT1 Functions in Leaf-to-Panicle Nitrogen Allocation for Grain Yield and Quality.Frontiers in plant science · 2020Article
- WRKY1 Mediates Transcriptional Regulation of Light and Nitrogen Signaling Pathways.Plant physiology · 2019Article
- Short-term inhibition of glutamine synthetase leads to reprogramming of amino acid and lipid metabolism in roots and leaves of tea plant (Camellia sinensis L.).BMC plant biology · 2019Article
- Providing carbon skeletons to sustain amide synthesis in roots underlines the suitability ofAoB PLANTS · 2019Article
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- Outgrowth of Rice Tillers Requires Availability of Glutamine in the Basal Portions of Shoots.Rice (New York, N.Y.) · 2018Article
- Characterization of natural leaf senescence in tobacco (Nicotiana tabacum) plants grown in vitro.Protoplasma · 2016Article
- Carbon: Nitrogen Interaction Regulates Expression of Genes Involved in N-Uptake and Assimilation in Brassica juncea L.PloS one · 2016Article
- Cytosolic glutamine synthetase is important for photosynthetic efficiency and water use efficiency in potato as revealed by high-throughput sequencing QTL analysis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- Glutamine rapidly induces the expression of key transcription factor genes involved in nitrogen and stress responses in rice roots.BMC genomics · 2015Article
- Control of Seed Germination and Plant Development by Carbon and Nitrogen Availability.Frontiers in plant science · 2015Review
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- Integrated analysis of transcriptome and metabolome of Arabidopsis albino or pale green mutants with disrupted nuclear-encoded chloroplast proteins.Plant molecular biology · 2014Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In bacteria and yeast, glutamine synthetase (GS) expression is tightly regulated by the metabolic status of the cell, both at the transcriptional and posttranscriptional levels. We discuss the relative contributions of light and metabolic cues on the regulation of members of the GS gene family (chloroplastic GS2 and cytosolic GS1) in Arabidopsis. These studies reveal that the dramatic induction of mRNA for chloroplastic GS2 by light is mediated in part by phytochrome and in part by light-induced changes in sucrose (Suc) levels. In contrast, the modest induction of mRNA for cytosolic GS1 by light is primarily mediated by changes in the levels of carbon metabolites. Suc induction of mRNA for GS2 and GS1 occurs in a time- and dose-dependent manner. Suc-induced changes in GS mRNA levels were also observed at the level of GS enzyme activity. In contrast, amino acids were shown to antagonize the Suc induction of GS, both at the level of mRNA accumulation and that of enzyme activity. For GS2, the gene whose expression was the most dramatically regulated by metabolites, we used a GS2 promoter-beta-glucuronidase fusion to demonstrate that transcriptional control is involved in this metabolic regulation. Our results suggest that the metabolic regulation of GS expression in plants is controlled by the relative abundance of carbon skeletons versus amino acids. This would allow nitrogen assimilation into glutamine to proceed (or not) according to the metabolic status and biosynthetic needs of the plant. This type of GS gene regulation is reminiscent of the nitrogen regulatory system in bacteria, and suggests an evolutionary link between metabolic sensing and signaling in bacteria and plants.
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