ArticleJournal of bacteriology1999
A nonessential signal peptidase II (Lsp) of Myxococcus xanthus might be involved in biosynthesis of the polyketide antibiotic TA.
Article in Journal of bacteriology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Corrigendum: Active substances of myxobacteria against plant diseases and their action mechanisms.Frontiers in microbiology · 2024Article
- Active substances of myxobacteria against plant diseases and their action mechanisms.Frontiers in microbiology · 2023Review
- Mode of action of lipoprotein modification enzymes-Novel antibacterial targets.Molecular microbiology · 2021Review
- Mechanisms of Transcriptional Pausing in Bacteria.Journal of molecular biology · 2019Review
- Genetic redundancy, proximity, and functionality of lspA, the target of antibiotic TA, in the Myxococcus xanthus producer strain.Journal of bacteriology · 2014Article
- Myxobacterium-produced antibiotic TA (myxovirescin) inhibits type II signal peptidase.Antimicrobial agents and chemotherapy · 2012Article
- Lipoproteins of bacterial pathogens.Infection and immunity · 2011Review
- Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes.Parasites & vectors · 2010Article
- The lspA gene, encoding the type II signal peptidase of Rickettsia typhi: transcriptional and functional analysis.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myxococcus xanthus is a gram-negative soil bacterium that produces the polyketide antibiotic TA. In this study, we describe the analysis of an M. xanthus gene which encodes a homologue of the prolipoprotein signal peptidase II (SPase II; lsp). Overexpression of the M. xanthus SPase II in Escherichia coli confers high levels of globomycin resistance, confirming its function as an SPase II. The M. xanthus gene encoding the lsp homologue is nonessential for growth, as determined by specific gene disruption. It has been mapped to the antibiotic TA gene cluster, and the disrupted mutants do not produce the antibiotic, indicating a probable involvement in TA production. These results suggest the existence of more than one SPase II protein in M. xanthus, where one is a system-specific SPase II (for TA biosynthesis).
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