Evidence map›Paper›PMID 10481969›Full record

ArticleInternational urology and nephrology1999

The role of autosomal cell apoptosis regulator genes in human spermatogenesis.

W W Lin, D J Lamb, L I Lipshultz, E D Kim

Abstract read
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. The CREM system in human spermatogenesis.Journal of endocrinological investigation · 2000
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

W W LinScott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
D J Lamb
L I Lipshultz
E D Kim
Baylor College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunohistochemical analysis of the expression of the autosomal apoptosis regulator genes, BAX, bcl-2, p53, and cyclic-AMP responsive element modulator (CREM) in testis biopsies from infertile men demonstrated that BAX, bcl-2, and p53 immunoreactivity was absent irrespective of seminiferous tubule histology. In contrast, cell-specific CREM immunoreactivity in round spermatids, with complete absence of CREM in patient biopsies showing spermatocyte maturation arrest and Sertoli cell only, was evident, suggesting a possible role of autosomal genes in the regulation of apoptosis in human spermatogenesis regulation.

Indexed as

Repressor ProteinsAdultApoptosisbcl-2-Associated X ProteinCyclic AMP Response Element ModulatorDNA-Binding ProteinsHumansImmunohistochemistryMaleOligospermiaProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Sertoli CellsSpermatidsSpermatocytesSpermatogenesisBAX protein, humanbcl-2-Associated X ProteinCyclic AMP Response Element ModulatorDNA-Binding ProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Repressor ProteinsTumor Suppressor Protein p53

Identifiers

PMID10481969
OpenAlexW97025852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.