ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Neuromuscular activity blockade induced by muscimol and d-tubocurarine differentially affects the survival of embryonic chick motoneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- A Latent Propriospinal Network Can Restore Diaphragm Function after High Cervical Spinal Cord Injury.Cell reports · 2017Article
- Motor Neurons Tune Premotor Activity in a Vertebrate Central Pattern Generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Glycinergic Neurotransmission: A Potent Regulator of Embryonic Motor Neuron Dendritic Morphology and Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Differential effects of RET and TRKB on axonal branching and survival of parasympathetic neurons.Developmental neurobiology · 2013Article
- Downregulation of GluA2 AMPA receptor subunits reduces the dendritic arborization of developing spinal motoneurons.PloS one · 2012Article
- Pharmacological manipulation of GABA-driven activity in ovo disrupts the development of dendritic morphology but not the maturation of spinal cord network activity.Neural development · 2010Article
- Inhibition of electrical activity by retroviral infection with Kir2.1 transgenes disrupts electrical differentiation of motoneurons.PloS one · 2008Article
- Differential effects of neurotrophins and schwann cell-derived signals on neuronal survival/growth and synaptogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Characterization of the circuits that generate spontaneous episodes of activity in the early embryonic mouse spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Activity- and target-dependent regulation of large-conductance Ca2+-activated K+ channels in developing chick lumbar motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Motoneuron survival is enhanced in the absence of neuromuscular junction formation in embryos.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Reduction of neuromuscular activity is required for the rescue of motoneurons from naturally occurring cell death by nicotinic-blocking agents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The pattern of avian intramuscular nerve branching is determined by the innervating motoneuron and its level of polysialic acid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
To understand better how spontaneous motoneuron activity and intramuscular nerve branching influence motoneuron survival, we chronically treated chicken embryos in ovo with either d-tubocurarine (dTC) or muscimol during the naturally occurring cell death period, assessing their effects on activity by in ovo motility measurement and muscle nerve recordings from isolated spinal cord preparations. Because muscimol, a GABA(A) agonist, blocked both spontaneous motoneuron bursting and that elicited by descending input but did not rescue motoneurons, we conclude that spontaneous bursting activity is not required for the process of normal motoneuron cell death. dTC, which rescues motoneurons and blocks neuromuscular transmission, blocked neither spontaneous nor descending input-elicited bursting and early in the cell death period actually increased burst amplitude. These changes in motoneuron activation could alter the uptake of trophic molecules or gene transcription via altered patterns of [Ca(2+)](i), which in turn could affect motoneuron survival directly or indirectly by altering intramuscular nerve branching. A good correlation was found between nerve branching and motoneuron survival under various experimental conditions: (1) dTC, but not muscimol, greatly increased branching; (2) the removal of PSA from NCAM partially reversed the effects of dTC on both branching and survival, indicating that branching is a critical variable influencing motoneuron survival; (3) muscimol, applied with dTC, prevented the effect of dTC on survival and motoneuron bursting and, to a large extent, its effect on branching. However, the central effects of dTC also appear to be important, because muscimol, which prevented motoneuron activity in the presence of dTC, also prevented the dTC-induced rescue of motoneurons.
Indexed as
Identifiers
10479694PMC6782443W2137112678What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.