ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Insulin prohormone processing, distribution, and relation to metabolism in Aplysia californica.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 121 citations in OpenAlex.
- PeptideMiner-neuropeptide discovery across the animal kingdom.GigaScience · 2025Article
- Insulin-like Peptide Receptor (ILPR) in the CuttlefishInternational journal of molecular sciences · 2022Article
- Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles.The Journal of biological chemistry · 2022Article
- Unconventional insulins from predators and pathogens.Nature chemical biology · 2022Review
- Characterization of Insulin-like Peptide (ILP) and Its Potential Role in Ovarian Development of the CuttlefishCurrent issues in molecular biology · 2022Article
- Identification, Synthesis, Conformation and Activity of an Insulin-like Peptide from a Sea Anemone.Biomolecules · 2021Article
- ATP signaling in the integrative neural center of Aplysia californica.Scientific reports · 2021Article
- Toxin-like neuropeptides in the sea anemoneProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The role of a new insulin-like peptide in the pearl oyster Pinctada fucata martensii.Scientific reports · 2020Article
- Exploring the Fundamental Structures of Life: Non-Targeted, Chemical Analysis of Single Cells and Subcellular Structures.Angewandte Chemie (International ed. in English) · 2019Review
- Role of PTP/PTK trans activated insulin-like signalling pathway in regulation of grasshopper (Oedaleus asiaticus) development.Environmental science and pollution research international · 2019Article
- Transcriptome analysis of air-breathing land slug, Incilaria fruhstorferi reveals functional insights into growth, immunity, and reproduction.BMC genomics · 2019Article
- Data for evolutive analysis of insulin related peptides in bilaterian species.Data in brief · 2019Article
- Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.ACS chemical neuroscience · 2018Review
- Identification and Characterization of Neuropeptides by Transcriptome and Proteome Analyses in a Bivalve MolluscFrontiers in genetics · 2018Article
- Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Review
- Hormone-like peptides in the venoms of marine cone snails.General and comparative endocrinology · 2017Article
- The Gastric Ganglion ofFrontiers in physiology · 2017Article
- Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa.Molecular biology and evolution · 2016Article
- Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The first Aplysia californica insulin gene is characterized and its proteolytic processing from prohormone to final peptides elucidated using a combination of biochemical and mass spectrometric methods. Aplysia insulin (AI) is one of the largest insulins found, with a molecular weight of 9146 Da, and an extended A chain compared with other invertebrate and vertebrate insulins. The AI prohormone produces a series of C peptides and also a unique N-terminally acetylated D peptide. AI-producing cells are restricted to the central region of the cerebral ganglia mostly within the F and C clusters, and AI is transported to neurohemal release sites located on the upper labial and anterior tentacular nerves. The expression of AI mRNA decreases when the animal is deprived of food, and injections of AI reduce hemolymph glucose levels, suggesting that the function of insulin-regulating metabolism has been conserved.
Indexed as
Identifiers
10479677PMC6782465W1943620375What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.