ArticleThe Journal of cell biology1999
The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- FAK mediates mechanical signaling to maintain epithelial homeostasis through YAP/TAZ-TEADs.Histochemistry and cell biology · 2025Article
- The Transcriptional Landscape of p53 Signalling Pathway.EBioMedicine · 2017Article
- Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.The Journal of biological chemistry · 2014Article
- Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath.The Journal of investigative dermatology · 2012Review
- Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins.Journal of cell science · 2011Article
- Differential modulation of keratin expression by sulforaphane occurs via Nrf2-dependent and -independent pathways in skin epithelia.Molecular biology of the cell · 2010Article
- Self-organization of keratin intermediate filaments into cross-linked networks.The Journal of cell biology · 2009Article
- Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility.The Journal of clinical investigation · 2009Review
- Mechanistic effects of long-term ultraviolet B irradiation induce epidermal and dermal changes in human skin xenografts.The American journal of pathology · 2009Article
- Keratinocyte migration, proliferation, and differentiation in chronic ulcers from patients with diabetes and normal wounds.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.Developmental biology · 2008Article
- Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A small surface hydrophobic stripe in the coiled-coil domain of type I keratins mediates tetramer stability.The Journal of cell biology · 2005Article
- Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.Molecular and cellular biology · 2005Article
- Keratin 17 null mice exhibit age- and strain-dependent alopecia.Genes & development · 2002Article
- Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments.Molecular biology of the cell · 2002Article
- The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro.The Journal of cell biology · 2001Article
- Increased levels of keratin 16 alter epithelialization potential of mouse skin keratinocytes in vivo and ex vivo.Molecular biology of the cell · 2001Article
- Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex.Molecular biology of the cell · 2001Article
- Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice.Molecular biology of the cell · 2001Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The type I epidermal keratins K14 and K16 are remarkably similar at the primary sequence level. While a structural function has been clearly defined for K14, we have proposed that a function of K16 may be to play a role in the process of keratinocyte activation that occurs after acute injury to stratified epithelia. To compare directly the functions of the two keratins we have targeted the expression of the human K16 cDNA to the progenitor basal layer of the epidermis of K14 null mice. Mice null for K14 blister extensively and die approximately 2 d after birth (Lloyd, C., Q.C. Yu, J. Cheng, K. Turksen, L. Degenstein, E. Hutton, and E. Fuchs. 1995. J. Cell Biol. 129:1329-1344). The skin of mice expressing K16 in the absence of K14 developed normally without evidence of blistering. However, as the mice aged they featured extensive alopecia, chronic epidermal ulcers in areas of frequent physical contact, and alterations in other stratified epithelia. Mice expressing a control K16-C14 cDNA also rescue the blistering phenotype of the K14 null mice with only a small percentage exhibiting minor alopecia. While K16 is capable of rescuing the blistering, phenotypic complementation in the resulting skin is incomplete due to the multiple age dependent anomalies. Despite their high sequence similarity, K16 and K14 are not functionally equivalent in the epidermis and other stratified epithelia and it is primarily the carboxy-terminal approximately 105 amino acids of K16 that define these differences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.