ArticleThe Journal of experimental medicine1999
Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 118 citations in OpenAlex.
- AIRR Community Guide to Planning and Performing AIRR-Seq Experiments.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes.Frontiers in immunology · 2017Article
- Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.Cell reports · 2016Article
- The analysis of clonal expansions in normal and autoimmune B cell repertoires.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.Journal of autoimmunity · 2015Article
- Contributions of B cells to lupus pathogenesis.Molecular immunology · 2014Review
- Trials and Tribulations with VH Replacement.Frontiers in immunology · 2014Review
- Somatic mutagenesis in autoimmunity.Autoimmunity · 2013Review
- Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity.The Journal of experimental medicine · 2013Article
- Secondary receptor editing in the generation of autoimmunity.Autoimmunity reviews · 2012Review
- Autoantibodies: Focus on anti-DNA antibodies.Self/nonself · 2011Article
- B cell receptor editing in tolerance and autoimmunity.Annals of the New York Academy of Sciences · 2011Review
- Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.The Journal of experimental medicine · 2010Article
- Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Patterns of receptor revision in the immunoglobulin heavy chains of a teleost fish.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3.Lupus · 2009Article
- Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.Arthritis and rheumatism · 2008Article
- The role of rearrangement at the second Ig heavy chain locus in maintaining B cell tolerance to DNA.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Editing and escape from editing in anti-DNA B cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Antibodies to single-stranded (ss)DNA are expressed in patients with systemic lupus erythematosus and in lupus-prone mouse models such as the MRL/Mp-lpr/lpr (MRL/lpr) strain. In nonautoimmune mice, B cells bearing immunoglobulin site-directed transgenes (sd-tgs) that code for anti-ssDNA are functionally silenced. In MRL/lpr autoimmune mice, the same sd-tgs are expressed in peripheral B cells and these autoantibodies gain the ability to bind other autoantigens such as double-stranded DNA and cell nuclei. These new specificities arise by somatic mutation of the anti-ssDNA sd-tgs and by secondary light chain rearrangement. Thus, B cells that in normal mice are anergic can be activated in MRL/lpr mice, which can lead to the generation of pathologic autoantibodies. In this paper, we provide the first direct evidence for peripheral rearrangement in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.