ArticleThe Journal of experimental medicine1999
Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer.Nature communications · 2026Article
- Glucose Requirement of Antigen-Specific Autoreactive B Cells and CD4+ T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease.Immunological reviews · 2019Review
- Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.Nature communications · 2016Article
- Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand.Immunity · 2016Article
- Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Genetic and cellular dissection of the activation of AM14 rheumatoid factor B cells in a mouse model of lupus.Journal of leukocyte biology · 2015Article
- Contributions of B cells to lupus pathogenesis.Molecular immunology · 2014Review
- Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Spontaneous loss of tolerance of autoreactive B cells in Act1-deficient rheumatoid factor transgenic mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation.Autoimmunity · 2010Article
- Regulation of autoreactive B cell responses to endogenous TLR ligands.Autoimmunity · 2010Review
- Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- B cells and immunological tolerance.The Journal of investigative dermatology · 2009Review
- Fas expression on antigen-specific T cells has costimulatory, helper, and down-regulatory functions in vivo for cytotoxic T cell responses but not for T cell-dependent B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells.Immunity · 2008Article
- Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Understanding B-cell tolerance through the use of immunoglobulin transgenic models.Immunologic research · 2008Review
- Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites.European journal of immunology · 2007Article
- B-cell anergy: from transgenic models to naturally occurring anergic B cells?Nature reviews. Immunology · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In systemic autoimmune disease, self-tolerance fails, leading to autoantibody production. A central issue in immunology is to understand the origins of activated self-reactive B cells. We have used immunoglobulin (Ig) transgenic mice to investigate the regulation of autoreactive B cells with specificity for self-IgG2a (the rheumatoid factor [RF] specificity) to understand how normal mice regulate RF autoantibodies and how this fails in autoimmune mice. We previously showed that normal mice do not tolerize the AM14 RF clone, nor do they appear to activate it. Here we show that in Fas-deficient autoimmune mice, the picture is quite different. RF B cells are activated to divide and secrete, but only when the autoantigen is present. Thus, B cells that are ignored rather than anergized in normal mice can be stimulated to produce autoantibody in Fas-deficient mice. This demonstrates a novel developmental step at which intact Fas-Fas ligand signaling is required to regulate B cells in order to prevent autoimmunity. These data also establish the relevance of ignorant self-specific B cells to autoantibody production in disease and prove that in the case of the RF specificity, the nominal autoantigen IgG2a is the driving autoantigen in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.