ReviewJournal of clinical pathology1999
Human papillomavirus and the development of non-melanoma skin cancer.
Review in Journal of clinical pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 96 citations in OpenAlex.
- Role of non-coding RNAs in human-papillomavirus-associated cutaneous neoplasms.Archives of virology · 2025Review
- Expression rates of p16, p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity.World journal of clinical cases · 2025Article
- Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis.Journal of virology · 2020Article
- In Vitro Organotypic Systems to Model Tumor Microenvironment in Human Papillomavirus (HPV)-Related Cancers.Cancers · 2020Review
- Association of Some High-Risk Mucosal Types ofIranian journal of pathology · 2019Article
- Long-term nitrite inhalant exposure and cancer risk in MSM.AIDS (London, England) · 2017Article
- Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation.PLoS pathogens · 2017Article
- The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors.Drug design, development and therapy · 2015Review
- HIV infection status, immunodeficiency, and the incidence of non-melanoma skin cancer.Journal of the National Cancer Institute · 2013Article
- Cutaneous squamous cell carcinoma and human papillomavirus: is there an association?Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2013Review
- Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma.The Journal of investigative dermatology · 2011Article
- The combined influence of oral contraceptives and human papillomavirus virus on cutaneous squamous cell carcinoma.Clinical Medicine Insights. Oncology · 2011Article
- Expression of p14ARF, p16INK4a and p53 in relation to HPV in (pre-)malignant squamous skin tumours.Journal of cellular and molecular medicine · 2009Article
- Cutaneous malignancies among HIV-infected persons.Archives of internal medicine · 2009Article
- Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study.AIDS (London, England) · 2009Article
- Molecular mechanisms of human papillomavirus-induced carcinogenesis.Public health genomics · 2009Review
- Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status.Molecular cancer therapeutics · 2007Article
- Human papillomavirus type 31b infection of human keratinocytes does not require heparan sulfate.Journal of virology · 2005Article
- Cervical cancer.Journal of clinical pathology · 2002Article
- Prevention of non-melanoma skin cancer.Current oncology reports · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human papillomaviruses (HPV) are increasingly recognised as important human carcinogens. The best established association with human malignancy is that of high-risk mucosal HPV types and anogenital cancer. HPV-induced transformation of anogenital epithelia has been the subject of intense research which has identified the cellular tumour suppressor gene products, p53 and pRB, as important targets for the viral oncoproteins E6 and E7 respectively. Certain HPV types are also strongly associated with the development of non-melanoma skin cancer in the inherited disorder epidermodysplasia verruciformis (EV). However, in contrast with anogenital malignancy the oncogenic mechanisms of EV-HPV types remain uncertain, and there appears to be a crucial additional requirement for ultraviolet radiation. Cutaneous HPV types in the general population are predominantly associated with benign viral warts, but a role in non-melanoma skin cancer has recently been postulated. Polymerase chain reaction based HPV detection techniques have shown a high prevalence of HPV DNA, particularly in skin cancers from immunosuppressed patients and to a lesser extent in malignancies from otherwise immunocompetent individuals. No particular HPV type has yet emerged as predominant, and the role of HPV in cutaneous malignancy is unclear at present. It remains to be established whether HPV plays an active or purely a passenger role in the evolution of non-melanoma skin cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.