ArticleMolecular biology of the cell1999
Fusion of endosomes involved in synaptic vesicle recycling.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 82 citations in OpenAlex.
- Vesicle3D: An Integrative Platform for 3D Segmentation and Analysis of Vesicles in Cryo-electron Tomograms.Neuroscience bulletin · 2026Article
- Identification of endoplasmic-reticulum-associated proteins involved in Bombyx mori nucleopolyhedrovirus entry by RNA-seq analysis.Archives of virology · 2022Article
- The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons.Communications biology · 2021Article
- Article
- Munc13-4 functions as a CaMolecular biology of the cell · 2017Article
- Calcium-dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel.Nature cell biology · 2014Article
- Ca²⁺-sensor proteins in the autophagic and endocytic traffic.Current protein & peptide science · 2013Review
- Synaptic vesicle generation from activity-dependent bulk endosomes requires calcium and calcineurin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.Brain research · 2012Article
- The expression of a naturally occurring, truncated allele of an α-SNAP gene suppresses plant parasitic nematode infection.Plant molecular biology · 2012Article
- Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells.American journal of physiology. Cell physiology · 2011Article
- The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.Cell calcium · 2011Review
- Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling.Trends in cell biology · 2010Review
- TRP channels of intracellular membranes.Journal of neurochemistry · 2010Review
- Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1.The Journal of biological chemistry · 2009Article
- C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes.Diabetologia · 2009Article
- The role of calcium in lipoprotein release by the low-density lipoprotein receptor.Biochemistry · 2009Article
- The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway.Traffic (Copenhagen, Denmark) · 2009Article
- Article
- SNARE function is not involved in early endosome docking.Molecular biology of the cell · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recycling of vesicles of the regulated secretory pathway presumably involves passage through an early endosomal compartment as an intermediate step. To learn more about the involvement of endosomes in the recycling of synaptic and secretory vesicles we studied in vitro fusion of early endosomes derived from pheochromocytoma (PC12) cells. Fusion was not affected by cleavage of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins synaptobrevin and syntaxin 1 that operate at the exocytotic limb of the pathway. Furthermore, fusion was inhibited by the fast Ca(2+) chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid but not by the slow Ca(2+) chelator EGTA. Endosome fusion was restored by the addition of Ca(2+) with an optimum at a free Ca(2+) concentration of 0.3 x 10(-6) M. Other divalent cations did not substitute for Ca(2+). A membrane-permeant EGTA derivative caused inhibition of fusion, which was reversed by addition of Ca(2+). We conclude that the fusion of early endosomes participating in the recycling of synaptic and neurosecretory vesicles is mediated by a set of SNAREs distinct from those involved in exocytosis and requires the local release of Ca(2+) from the endosomal interior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.