ArticleMolecular biology of the cell1999
Division of labor among the alpha6beta4 integrin, beta1 integrins, and an E3 laminin receptor to signal morphogenesis and beta-casein expression in mammary epithelial cells.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 119 citations in OpenAlex.
- Volumetric printed biomimetic scaffolds support in vitro lactation of human milk-derived mammary epithelial cells.Science advances · 2025Article
- The microstructure of laminin-111 compensates for dystroglycan loss in mammary epithelial cells in downstream expression of milk proteins.Biomaterials · 2019Article
- Organoids: A historical perspective of thinking in three dimensions.The Journal of cell biology · 2017Review
- Modular GAG-matrices to promote mammary epithelial morphogenesis in vitro.Biomaterials · 2017Article
- Dynamic reciprocity between cells and their microenvironment in reproduction.Biology of reproduction · 2015Review
- β1 and β4 integrins: from breast development to clinical practice.Breast cancer research : BCR · 2014Review
- Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways.The Journal of clinical investigation · 2014Article
- NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals.Oncotarget · 2013Article
- Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells.Differentiation; research in biological diversity · 2013Article
- Article
- Three-dimensional cultures of mouse mammary epithelial cells.Methods in molecular biology (Clifton, N.J.) · 2013Article
- SnoN regulates mammary gland alveologenesis and onset of lactation by promoting prolactin/Stat5 signaling.Development (Cambridge, England) · 2012Article
- Introduction of SV40ER and hTERT into mammospheres generates breast cancer cells with stem cell properties.Oncogene · 2012Article
- Article
- Role of DDR1 in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 breast cancer cells.Clinical & experimental metastasis · 2011Article
- Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo.Genes & development · 2010Article
- Dystroglycan controls signaling of multiple hormones through modulation of STAT5 activity.Journal of cell science · 2010Article
- Laminin regulates PI3K basal localization and activation to sustain STAT5 activation.Cell cycle (Georgetown, Tex.) · 2010Article
- Cell-matrix interactions in mammary gland development and breast cancer.Cold Spring Harbor perspectives in biology · 2010Review
- The contribution of adhesion signaling to lactogenesis.Journal of cell communication and signaling · 2010Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Contact of cultured mammary epithelial cells with the basement membrane protein laminin induces multiple responses, including cell shape changes, growth arrest, and, in the presence of prolactin, transcription of the milk protein beta-casein. We sought to identify the specific laminin receptor(s) mediating the multiple cell responses to laminin. Using assays with clonal mammary epithelial cells, we reveal distinct functions for the alpha6beta4 integrin, beta1 integrins, and an E3 laminin receptor. Signals from laminin for beta-casein expression were inhibited in the presence of function-blocking antibodies against both the alpha6 and beta1 integrin subunits and by the laminin E3 fragment. The alpha6-blocking antibody perturbed signals mediated by the alpha6beta4 integrin, and the beta1-blocking antibody perturbed signals mediated by another integrin, the alpha subunit(s) of which remains to be determined. Neither alpha6- nor beta1-blocking antibodies perturbed the cell shape changes resulting from cell exposure to laminin. However, the E3 laminin fragment and heparin both inhibited cell shape changes induced by laminin, thereby implicating an E3 laminin receptor in this function. These results elucidate the multiplicity of cell-extracellular matrix interactions required to integrate cell structure and signaling and ultimately permit normal cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.