ArticleThe Journal of biological chemistry1999
Regulation of the Dlx3 homeobox gene upon differentiation of mouse keratinocytes.
Article in The Journal of biological chemistry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Chromatin Landscape Governing Murine Epidermal Differentiation.The Journal of investigative dermatology · 2023Article
- Rab25 Deficiency Perturbs Epidermal Differentiation and Skin Barrier Function in Mice.Biomolecules & therapeutics · 2019Article
- Do DLX3 and CD271 Protect Human Keratinocytes from Squamous Tumor Development?International journal of molecular sciences · 2019Article
- A novel DLX3-PKC integrated signaling network drives keratinocyte differentiation.Cell death and differentiation · 2017Article
- The homeoprotein DLX3 and tumor suppressor p53 co-regulate cell cycle progression and squamous tumor growth.Oncogene · 2016Article
- Matrix metalloproteinase 9 is a distal-less 3 target-gene in placental trophoblast cells.American journal of physiology. Cell physiology · 2013Article
- Theria-specific homeodomain and cis-regulatory element evolution of the Dlx3-4 bigene cluster in 12 different mammalian species.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2012Article
- Distal-less 3 haploinsufficiency results in elevated placental oxidative stress and altered fetal growth kinetics in the mouse.Placenta · 2012Article
- Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation.Cell cycle (Georgetown, Tex.) · 2009Article
- Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers.Journal of cellular and molecular medicine · 2008Article
- A 4 bp deletion mutation in DLX3 enhances osteoblastic differentiation and bone formation in vitro.Bone · 2008Article
- Dlx genes, p63, and ectodermal dysplasias.Birth defects research. Part C, Embryo today : reviews · 2005Review
- Article
- Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.Molecular and cellular biology · 2004Article
- A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes.BMC dermatology · 2004Article
- Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes.Nucleic acids research · 2002Article
- Characterization of human cathepsin L promoter and identification of binding sites for NF-Y, Sp1 and Sp3 that are essential for its activity.The Biochemical journal · 2002Article
- Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C.FEBS letters · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Distal-less Dlx3 homeodomain gene is expressed in terminally differentiated murine epidermal cells, and there is evidence to support an essential role as a transcriptional regulator of the terminal differentiation process in these cells. In an attempt to determine the factors that induce Dlx3 gene expression, we have cloned the 1.2-kilobase pair proximal region of murine gene and analyzed its cis-regulatory elements and potential trans-acting factors. The proximal region of the Dlx3 gene has a canonical TATA box and CCAAT box, and the transcription start site was located 205 base pairs upstream from the initiation of translation site. Serial deletion analysis showed that the region between -84 and -34 confers the maximal promoter activity both in undifferentiated and differentiated primary mouse keratinocytes. Gel retardation assays and mutational analysis demonstrated that the transcriptional regulator NF-Y (also referred to as CBF) binds to a CCAAT box motif within this region and is responsible for the majority of the Dlx3 promoter activity. In addition, an Sp1-binding site was located immediately upstream of transcription start site that acts as a positive regulatory element of the Dlx3 promoter, independent of the CCAAT box motif. Importantly, elements residing between +30 to +60 of the Dlx3 gene are responsible for the Ca(2+)-dependent induction of Dlx3 during keratinocyte differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.