Evidence map›Paper›PMID 10473477›Full record

Trial reportBMJ (Clinical research ed.)1999

Effect of antidepressant drug counselling and information leaflets on adherence to drug treatment in primary care: randomised controlled trial.

R Peveler, C George, A L Kinmonth, M Campbell, C Thompson

Open access · bronzeAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 10 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 10 syntheses or guidelines pooled it, 258 citations in OpenAlex.

  1. Collaborative care approaches for people with severe mental illness.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014
    Pooled it
  3. Relapse prevention after index electroconvulsive therapy in treatment-resistant depression.Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · 2014
    Pooled it
  4. Collaborative care for depression and anxiety problems.The Cochrane database of systematic reviews · 2012
    Pooled it
  5. Written information about individual medicines for consumers.The Cochrane database of systematic reviews · 2009
    Pooled it
  6. Pooled it
  7. Psychosocial interventions by general practitioners.The Cochrane database of systematic reviews · 2007
    Pooled it
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  9. Primary care mental health workers: models of working and evidence of effectiveness.The British journal of general practice : the journal of the Royal College of General Practitioners · 2002
    Pooled it
  10. The clinical and cost-effectiveness of self-help treatments for anxiety and depressive disorders in primary care: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2001
    Pooled it
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

R PevelerMental Health Group, University of Southampton, Royal South Hants Hospital, Southampton SO14 0YG. rcp@soton.ac.uk
C George
A L Kinmonth
M Campbell
C Thompson
University of Southampton · GBUniversity of Cambridge · GBUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate two different methods of improving adherence to antidepressant drugs.

designFactorial randomised controlled single blind trial of treatment leaflet, drug counselling, both, or treatment as usual.

settingPrimary care in Wessex

participants250 patients starting treatment with tricyclic antidepressants.

main outcome measuresAdherence to drug treatment (by confidential self report and electronic monitor); depressive symptoms and health status.

results66 (63%) patients continued with drugs to 12 weeks in the counselled group compared with 42 (39%) of those who did not receiving counselling (odds ratio 2.7, 95% confidence interval 1.6 to 4.8; number needed to treat=4). Treatment leaflets had no significant effect on adherence. No differences in depressive symptoms were found between treatment groups overall, although a significant improvement was found in patients with major depressive disorder receiving drug doses of at least 75 mg (depression score 4 (SD 3.7) counselling v 5.9 (SD 5.0) no counselling, P=0.038).

conclusionsCounselling about drug treatment significantly improved adherence, but clinical benefit was seen only in patients with major depressive disorder receiving doses >/=75 mg. Further research is required to evaluate the effect of this approach in combination with appropriate targeting of treatment and advice about dosage.

Indexed as

Patient ComplianceAdultAgedAged, 80 and overAntidepressive AgentsDepressive DisorderFamily PracticeFemaleFollow-Up StudiesHumansMaleMiddle AgedPatient Education as TopicSurvival AnalysisTreatment OutcomeAntidepressive Agents

Identifiers

PMID10473477
PMCPMC28214
OpenAlexW2168206583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.