ArticleJournal of muscle research and cell motility1999
Utrophin and dystrophin-associated glycoproteins in normal and dystrophin deficient cardiac muscle.
Article in Journal of muscle research and cell motility, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Nuclear import of β-dystroglycan is facilitated by ezrin-mediated cytoskeleton reorganization.PloS one · 2014Article
- Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.PLoS genetics · 2012Article
- Dystrophin and utrophin isoforms are expressed in glia, but not neurons, of the avian parasympathetic ciliary ganglion.Brain research · 2008Article
- Pathological pattern of Mdx mice diaphragm correlates with gradual expression of the short utrophin isoform Up71.Biochimica et biophysica acta · 2006Article
- A novel isoform of delta-sarcoglycan is localized at the sarcoplasmic reticulum of mouse skeletal muscle.Biochemical and biophysical research communications · 2006Article
- The sarcoglycan-sarcospan complex localization in mouse retina is independent from dystrophins.Neuroscience research · 2005Article
- Dystrophin-associated proteins in obliquely striated muscle of the leech Pontobdella muricata (Annelida, Hirudinea).The Histochemical journal · 2001Article
- Absence of utrophin in intercalated discs of human cardiac muscle.The Histochemical journal · 2001Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, various members of the dystrophin family (dystrophin, the short dystrophin product Dp 71, utrophin and DRP2), and different members of the dystrophin-associated glycoprotein (DAG) complex (beta-dystroglycan, alpha-, beta-, gamma- and delta-sarcoglycans) were localized in bovine cardiac muscle using a battery of specific antibodies. We have established that dystrophin is exclusively associated with beta-dystroglycan and both alpha- and delta-sarcoglycans in cardiac muscle cell membranes. In contrast, utrophin is a specific component of intercalated disks together with beta- and gamma-sarcoglycans, while beta-dystroglycan, alpha- and delta-sarcoglycans are not present. Dp 71 is mainly localized at the T tubule transverse area. In dystrophin deficient cardiac muscle, utrophin and beta-sarcoglycan were observed in intercalated disks and at the sarcolemma of each cardiocyte. Our results revealed that complexes of associated glycoproteins differ in cardiac muscle when associated with dystrophin or utrophin. Despite the described sequence homologies between dystrophin and utrophin, the present results indicate that these proteins have different roles in some specific cardiac cell areas.
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