ArticleGenetics1999
Genetic dissection of X-linked interspecific hybrid placental dysplasia in congenic mouse strains.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Fundamental and unique roles of PLAC1 in the regulation of rat and human trophoblast cell development.Development (Cambridge, England) · 2026Article
- Evolution of Gene Expression Across Functional Regions of the Mouse Placenta.Genome biology and evolution · 2026Article
- Overexpression of placenta-specific noncanonical imprinted genes causes placental enlargement in intersubspecific hybrid mice†.Biology of reproduction · 2026Article
- Creation of true interspecies hybrids: Rescue of hybrid class with hybrid cytoplasm affecting growth and metabolism.Science advances · 2024Article
- United by conflict: Convergent signatures of parental conflict in angiosperms and placental mammals.The Journal of heredity · 2024Review
- X chromosome-dependent disruption of placental regulatory networks in hybrid dwarf hamsters.Genetics · 2021Article
- OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR.Developmental biology · 2020Article
- Parent-of-origin growth effects and the evolution of hybrid inviability in dwarf hamsters.Evolution; international journal of organic evolution · 2014Article
- The nexus of prematurity, birth defects, and intrauterine growth restriction: a role for plac1-regulated pathways.Frontiers in pediatrics · 2014Review
- Plac1 (placenta-specific 1) is essential for normal placental and embryonic development.Molecular reproduction and development · 2012Article
- RXRα and LXR activate two promoters in placenta- and tumor-specific expression of PLAC1.Placenta · 2011Article
- Chromosome-substituted rat strains provide insights into the genetics of placentation.Physiological genomics · 2011Article
- PLAC1 (Placenta-specific 1): a novel, X-linked gene with roles in reproductive and cancer biology.Prenatal diagnosis · 2010Review
- Article
- Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- The PLAC1-homology region of the ZP domain is sufficient for protein polymerisation.BMC biochemistry · 2006Article
- Conservation of genomic imprinting at the XIST, IGF2, and GTL2 loci in the bovine.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Genetic analysis of X-linked hybrid sterility in the house mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Cited1 is required in trophoblasts for placental development and for embryo growth and survival.Molecular and cellular biology · 2004Article
- DNA methylation in placentas of interspecies mouse hybrids.Genetics · 2003Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Interspecific hybridization in the genus Mus results in male sterility and X-linked placental dysplasia. We have generated several congenic laboratory mouse lines (Mus musculus) in which different parts of the maternal X chromosome were derived from M. spretus. A strict positive correlation between placental weight and length of the M. spretus-derived part of the X chromosome was shown. Detailed analysis was carried out with one congenic strain that retained a M. spretus interval between 12.0 and 30.74 cM. This strain consistently produced hyperplastic placentas that exhibited an average weight increase of 180% over the weight of control placentas. In derived subcongenic strains, however, increased placental weight could no longer be observed. Morphometric analysis of these placentas revealed persistence of abnormal morphology. Fully developed placental hyperplasia could be reconstituted by recombination of proximal and central M. spretus intervals with an intervening M. musculus region. These results may suggest that placental dysplasia of interspecific mouse hybrids is caused by multiple loci clustered on the X chromosome that act synergistically. Alternatively, it is possible that changes in chromatin structure in interspecific hybrids that influence gene expression are dependent on the length of the alien chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.