ArticleGenetics1999
An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.
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Who cites it
119 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.Genome biology · 2002Pooled it
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- Functional innovation through new genes as a general evolutionary process.Nature genetics · 2025Review
- Fourth Chromosome Resource Project: a comprehensive resource for genetic analysis in Drosophila that includes humanized stocks.Genetics · 2024Article
- Essential functions of RNA helicase Vasa in maintaining germline stem cells and piRNA-guidedFrontiers in cell and developmental biology · 2024Article
- Demonstration of in vivo engineered tandem duplications of varying sizes using CRISPR and recombinases in Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Demonstration ofbioRxiv : the preprint server for biology · 2023Article
- Comparative Genomic Analysis of the DUF34 Protein Family Suggests Role as a Metal Ion Chaperone or Insertase.Biomolecules · 2021Article
- Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development.PLoS genetics · 2021Article
- Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.PLoS genetics · 2021Article
- Rapid Evolution of Gained Essential Developmental Functions of a Young Gene via Interactions with Other Essential Genes.Molecular biology and evolution · 2019Article
- Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 inG3 (Bethesda, Md.) · 2019Article
- A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.PLoS genetics · 2018Article
- Mapping Second Chromosome Mutations to Defined Genomic Regions inG3 (Bethesda, Md.) · 2018Article
- The Gene Expression Program for the Formation of Wing Cuticle in Drosophila.PLoS genetics · 2016Article
- Computational Identification of Novel Genes: Current and Future Perspectives.Bioinformatics and biology insights · 2016Review
- Cropped, Drosophila transcription factor AP-4, controls tracheal terminal branching and cell growth.BMC developmental biology · 2015Article
- Loss of Pol32 in Drosophila melanogaster causes chromosome instability and suppresses variegation.PloS one · 2015Article
- Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila.eLife · 2014Article
59 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors.
Funding
Abstract
A contiguous sequence of nearly 3 Mb from the genome of Drosophila melanogaster has been sequenced from a series of overlapping P1 and BAC clones. This region covers 69 chromosome polytene bands on chromosome arm 2L, including the genetically well-characterized "Adh region." A computational analysis of the sequence predicts 218 protein-coding genes, 11 tRNAs, and 17 transposable element sequences. At least 38 of the protein-coding genes are arranged in clusters of from 2 to 6 closely related genes, suggesting extensive tandem duplication. The gene density is one protein-coding gene every 13 kb; the transposable element density is one element every 171 kb. Of 73 genes in this region identified by genetic analysis, 49 have been located on the sequence; P-element insertions have been mapped to 43 genes. Ninety-five (44%) of the known and predicted genes match a Drosophila EST, and 144 (66%) have clear similarities to proteins in other organisms. Genes known to have mutant phenotypes are more likely to be represented in cDNA libraries, and far more likely to have products similar to proteins of other organisms, than are genes with no known mutant phenotype. Over 650 chromosome aberration breakpoints map to this chromosome region, and their nonrandom distribution on the genetic map reflects variation in gene spacing on the DNA. This is the first large-scale analysis of the genome of D. melanogaster at the sequence level. In addition to the direct results obtained, this analysis has allowed us to develop and test methods that will be needed to interpret the complete sequence of the genome of this species. Before beginning a Hunt, it is wise to ask someone what you are looking for before you begin looking for it. Milne 1926
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