Trial reportAntimicrobial agents and chemotherapy1999
Randomized, double-blind trial of an antibiotic-lock technique for prevention of gram-positive central venous catheter-related infection in neutropenic patients with cancer.
Trial report in Antimicrobial agents and chemotherapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00122642 (Short Daily Alcohol Locks for the Prevention of Tunneled Catheter Infection in Patients With Haematological Disease. Randomised Placebo Controlled Trial), which is not on this map. Cited by 36 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short Daily Alcohol Locks for the Prevention of Tunneled Catheter Infection in Patients With Haematological Disease. Randomised Placebo Controlled Trial
Who cites it
36 citing papers in PubMed, 7 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.The Cochrane database of systematic reviews · 2022Pooled it
- Prophylactic antibiotics for preventing gram-positive infections associated with long-term central venous catheters in adults and children receiving treatment for cancer.The Cochrane database of systematic reviews · 2021Pooled it
- Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Prophylactic antibiotics for preventing Gram positive infections associated with long-term central venous catheters in oncology patients.The Cochrane database of systematic reviews · 2013Pooled it
- Guidelines for the prevention of intravascular catheter-related infections: recommendations relevant to interventional radiology for venous catheter placement and maintenance.Journal of vascular and interventional radiology : JVIR · 2012Guideline
- Summary of recommendations: Guidelines for the Prevention of Intravascular Catheter-related Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Guideline
- Vancomycin for prophylaxis against sepsis in preterm neonates.The Cochrane database of systematic reviews · 2000Pooled it
- A Randomized, Double-Blind, Placebo-Controlled Trial (TAURCAT Study) of Citrate Lock Solution for Prevention of Endoluminal Central Venous Catheter Infection in Neutropenic Hematological Patients.Antimicrobial agents and chemotherapy · 2020Trial
- Trial
- Bacterial infections in pediatric oncology patients- a single center experience.Scientific reports · 2025Article
- Antimicrobial Lock Therapy in Clinical Practice: A Scoping Review.Microorganisms · 2025Review
- Differences in Efficacy between Antibacterial Lock Therapy and the Standard of Care for CVC-Related Infections: A Systematic Review and Meta-Analysis.Clinics and practice · 2024Review
- Review
- Catheter-related blood stream infections: prevalence, risk factors and antimicrobial resistance pattern.Medical journal, Armed Forces India · 2021Article
- Indian Society of Critical Care Medicine Position Statement for Central Venous Catheterization and Management 2020.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Prevalence of and risk factors for intravenous catheter infection in hospitalized cattle, goats, and sheep.Journal of veterinary internal medicine · 2020Article
- Article
- Bloodstream infections in patients with solid tumors.Virulence · 2016Review
- Effects of bacteriocins on methicillin-resistant Staphylococcus aureus biofilm.Antimicrobial agents and chemotherapy · 2013Article
- Full and broad-spectrum in vivo eradication of catheter-associated biofilms using gentamicin-EDTA antibiotic lock therapy.Antimicrobial agents and chemotherapy · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to determine the efficacy of an antibiotic-lock technique in preventing endoluminal catheter-related infection with gram-positive bacteria in neutropenic patients with hematologic malignancies. Patients with nontunneled, multilumen central venous catheters were assigned in a randomized, double-blinded manner to receive either 10 U of heparin per ml (57 patients) or 10 U of heparin per ml and 25 microg of vancomycin per ml (60 patients), which were instilled in the catheter lumen and which were allowed to dwell in the catheter lumen for 1 h every 2 days. Insertion-site and hub swabs were taken twice weekly. The primary and secondary end points of the trial were significant colonization of the catheter hub and catheter-related bacteremia, respectively. Significant colonization of the catheter hub occurred in nine (15.8%) patients receiving heparin (seven patients were colonized with Staphylococcus epidermidis, one patient was colonized with Staphylococcus capitis, and one patient was colonized with Corynebacterium sp.), whereas the catheter hubs of none of the patients receiving heparin and vancomycin were colonized (P = 0.001). Catheter-related bacteremia developed in four (7%) patients receiving heparin (three patients had S. epidermidis bacteremia and one patient had S. capitis bacteremia), whereas none of the patients in the heparin and vancomycin group had catheter-related bacteremia (P = 0.05). The times to catheter hub colonization and to catheter-related bacteremia by the Kaplan-Meier method were longer in patients receiving heparin and vancomycin than in patients receiving heparin alone (P = 0.004 and P = 0.06, respectively). Our study shows that a solution containing heparin and vancomycin administered by using an antibiotic-lock technique effectively prevents catheter hub colonization with gram-positive bacteria and subsequent bacteremia during chemotherapy-induced neutropenia in patients with hematologic malignancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.