ReviewInternational journal of experimental pathology1999
The role of cell cycle-mediated events in Alzheimer's disease.
Review in International journal of experimental pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 225 citations in OpenAlex.
- Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer's Disease.Nutrients · 2025Review
- Alzheimer's Disease-Related Genes Identified by Linking Spatial Patterns of Pathology and Gene Expression.Frontiers in neuroscience · 2022Article
- Clustering of Alzheimer's and Parkinson's disease based on genetic burden of shared molecular mechanisms.Scientific reports · 2020Article
- Contributions of Molecular and Optical Techniques to the Clinical Diagnosis of Alzheimer's Disease.Brain sciences · 2020Review
- Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila.Scientific reports · 2020Article
- Death-Associated Protein Kinase 1 as a Promising Drug Target in Cancer and Alzheimer's Disease.Recent patents on anti-cancer drug discovery · 2019Review
- Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways.BMC neuroscience · 2015Review
- Synopsis on the linkage of Alzheimer's and Parkinson's disease with chronic diseases.CNS neuroscience & therapeutics · 2015Review
- Alzheimer's disease: amino acid levels and brain metabolic status.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- Glycogen synthase kinase 3 β activity is required for hBora/Aurora A-mediated mitotic entry.Cell cycle (Georgetown, Tex.) · 2013Article
- G1/S cell cycle checkpoint defect in lymphocytes from patients with Alzheimer's disease.Psychiatry investigation · 2012Article
- The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.Journal of neuropathology and experimental neurology · 2011Article
- Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?Journal of Alzheimer's disease : JAD · 2011Article
- Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease.Neurochemistry international · 2009Review
- Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity.Journal of molecular medicine (Berlin, Germany) · 2008Article
- Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.International journal of clinical and experimental pathology · 2008Article
- Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons.Journal of molecular neuroscience : MN · 2005Article
- "Sleeping beauty": quiescence in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2004Review
- A peptide derived from acetylcholinesterase induces neuronal cell death: characterisation of possible mechanisms.Experimental brain research · 2003Article
- Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4.Journal of virology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism(s) underlying selective neuronal death in Alzheimer's disease remain unresolved. However, recently, we and others showed that susceptible hippocampal neurones in Alzheimer's disease express markers common to cells in various phases of the cell cycle. Since neuronal maturation is associated with effective escape from the cell division cycle, emergence out of quiescence may be deleterious. Here, we review a number of current findings indicating that disregulated ectopic re-activation of cell cycle-mediated events, akin to neoplasia, represent an important early pathway associated with neuronal death and, more importantly, one that involves virtually the entire spectrum of the pathological events described in Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.