ArticleClinical and experimental immunology1999
Spleen autotransplantation provides restoration of functional splenic lymphoid compartments and improves the humoral immune response to pneumococcal polysaccharide vaccine.
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- The Impact of Heterotopic Spleen Regeneration on Tumor Growth.FASEB bioAdvances · 2026Article
- Spleen autotransplantation on liver versus greater omentum for simultaneous injuries of liver and spleen: an experimental study.Annals of medicine and surgery (2012) · 2024Article
- Article
- Spleen: Reparative Regeneration and Influence on Liver.Life (Basel, Switzerland) · 2022Review
- Critical mass of splenic autotransplant needed for the development of phagocytic activity in rats.Clinical and experimental immunology · 2012Article
- Article
- Staphylococcus aureus infection after splenectomy and splenic autotransplantation in BALB/c mice.Clinical and experimental immunology · 2008Article
- Effect of non-operative management (NOM) of splenic rupture versus splenectomy on the distribution of peripheral blood lymphocyte populations and cytokine production by T cells.Clinical and experimental immunology · 2007Article
- Splenic autotransplantation and oesophageal transection anastomosis in patients with portal hypertension (26 years clinical observation).Frontiers of medicine in China · 2007Article
- Antibody response of autogenous splenic tissue implanted in the abdominal cavity of mice.World journal of surgery · 2005Article
- Laparoscopic hand-assisted spleen autotransplantation.Surgical endoscopy · 2004Article
- After chemotherapy, functional humoral response capacity is restored before complete restoration of lymphoid compartments.Clinical and experimental immunology · 2003Article
- The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens.Clinical and experimental immunology · 2002Review
- Pneumococcal conjugate vaccines overcome splenic dependency of antibody response to pneumococcal polysaccharides.Infection and immunity · 2001Article
- Regeneration of autotransplanted splenic fragments: basic immunological and clinical relevance.Clinical and experimental immunology · 1999Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After splenectomy, patients have an increased risk of overwhelming post-splenectomy infection (OPSI) or sepsis involving encapsulated bacteria such as pneumococcus. The value of spleen autotransplantation after splenectomy because of trauma has long been questioned. Much attention has been given to the restoration of mononuclear phagocyte system (MPS) function, which appeared to be similar to that of splenectomized individuals. The presence of specific anti-pneumococcal antibodies may enhance phagocytosis of opsonized bacteria by other parts of the MPS, as present in the liver. Therefore, in the present study we have evaluated the restoration of the humoral immune response after spleen autotransplantation, especially to pneumococcal capsular polysaccharides (PPS). Wistar rats were divided into three groups which were operated as follows: splenectomy, splenectomy followed by autotransplantation, and sham operation. After 12 weeks the rats were vaccinated with 23-valent pneumococcal vaccine. Blood samples were taken after 3 days, 3 and 6 weeks for anti-PPS IgM and IgG ELISA against types 3, 4, 6, 9, 14 and 23. In addition, immunohistological studies were performed on the autotransplants. Significant antibody titre rises were found in a main proportion of the autotransplanted rats, comparable to sham-operated rats. Splenectomized rats showed as well a significantly lower increase in immunoglobulin levels, as significant differences in the proportion of rats showing a minimum two-fold increase of antibody level, considered to represent an adequate response. The titres were highest 3 days after vaccination. Immunohistochemical studies demonstrated structurally functional autotransplants, including an intact marginal zone. Considering this significant anti- pneumococcal antibody response, spleen autotransplants can be expected to enable an improved humoral response to PPS, and to contribute to protection against OPSI after splenectomy.
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