ArticleClinical and experimental immunology1999
Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 107 citations in OpenAlex.
- Article
- Advances in Psoriasis Research: Decoding Immune Circuits and Developing Novel Therapies.International journal of molecular sciences · 2025Review
- Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.Biomolecules · 2023Article
- Group AScience immunology · 2023Article
- Anti-Psoriatic Effects of Antimony Compounds In Vitro.Molecules (Basel, Switzerland) · 2021Article
- The Role of Helper T Cells in Psoriasis.Frontiers in immunology · 2021Review
- The contribution of IL-17 to the development of autoimmunity in psoriasis.Innate immunity · 2019Review
- Review
- Adaptive and Innate Immunity in Psoriasis and Other Inflammatory Disorders.Frontiers in immunology · 2019Review
- Unmet Needs in the Field of Psoriasis: Pathogenesis and Treatment.Clinical reviews in allergy & immunology · 2018Review
- Psoriasis patients demonstrate HLA-Cw*06:02 allele dosage-dependent T cell proliferation when treated with hair follicle-derived keratin 17 protein.Scientific reports · 2018Article
- Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis.Frontiers in immunology · 2018Review
- T Cell Hierarchy in the Pathogenesis of Psoriasis and Associated Cardiovascular Comorbidities.Frontiers in immunology · 2018Review
- Effect of Calcipotriol on IFN-γ-Induced Keratin 17 Expression in Immortalized Human Epidermal Keratinocyte Cells.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Psoriasis: a mixed autoimmune and autoinflammatory disease.Current opinion in immunology · 2017Review
- The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C*06:02 molecule.The Journal of biological chemistry · 2017Article
- The Quest for Psoriasis Autoantigens: Genetics Meets Immunology in the Melanocyte.The Journal of investigative dermatology · 2017Article
- [Autoimmune reactions in psoriasis : Spotlight].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2016Review
- Interactions between host factors and the skin microbiome.Cellular and molecular life sciences : CMLS · 2015Review
- The IL-17A-producing CD8+ T-cell population in psoriatic lesional skin comprises mucosa-associated invariant T cells and conventional T cells.The Journal of investigative dermatology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psoriasis is a T cell-mediated inflammatory skin disease that has been associated with infections by group A beta-haemolytic streptococci. In a previous study of patients with active psoriasis we demonstrated an increased frequency of circulating Th1-like cells that responded to 20 amino acid (aa) streptococcal M-peptides sharing sequences with human keratin. These cells disappeared after ultraviolet B (UVB)-induced clinical remission. Using T cells from the blood of 17 psoriatic patients and 17 healthy controls we have now compared the numbers of interferon-gamma (IFN-gamma)-producing cells induced by seven 18-20 aa keratin peptides and five corresponding M-peptides. The most frequent and strongest responses were observed to a peptide from keratin 17 that shares ALEEAN sequence with M-protein. The responses to this peptide were stronger than to the corresponding M-peptide containing the ALEEAN sequence. After UVB treatment T cell responses to all the M- and keratin peptides were abolished, while responses to the positive control antigen streptokinase/streptodornase (SK/SD) were not affected. These findings are consistent with the notion that aa sequences which keratin has in common with M-protein may be a major target for autoreactive T cells in psoriasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.