ArticleClinical and experimental immunology1999
A switch towards Th2 during serological rebound in children with congenital toxoplasmosis.
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Th1 and Th2 immune response to P30 and ROP18 peptides in human toxoplasmosis.Medical microbiology and immunology · 2014Article
- Spiramycin treatment of Toxoplasma gondii infection in pregnant women impairs the production and the avidity maturation of T. gondii-specific immunoglobulin G antibodies.Clinical and vaccine immunology : CVI · 2009Article
- Heterogeneity in cellular and humoral immune responses against Toxoplasma gondii antigen in humans.Clinical and experimental immunology · 2004Article
- Cellular immunity to Toxoplasma gondii in congenitally infected newborns and immunocompetent infected hosts.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2003Article
- Cellular immune responses to recombinant antigens in pregnant women chronically infected with Toxoplasma gondii.Clinical and diagnostic laboratory immunology · 2002Article
- Systemic T cell response to Toxoplasma gondii antigen in patients with ocular toxoplasmosis.Japanese journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serological rebounds occur frequently in patients with congenital toxoplasmosis, but remain poorly understood. A link between Th1 and Th2 cytokines and the pathophysiology of infectious diseases has been reported. Production of interferon-gamma (IFN-gamma) and IL-4 in supernatants of whole blood after in vitro specific Toxoplasma gondii stimulation and serum-specific IgE levels were studied in 31 congenitally infected children. IFN-gamma was produced at higher levels by lymphocytes from children with stable congenital toxoplasmosis (n = 18) than from children showing serological rebound (n = 13) (P < 0.04). Conversely, supernatants from children with serological rebound showed higher levels of IL-4 than those from children with stable congenital toxoplasmosis (P < 0.03). The polarized Th2 response was confirmed by a greater (IL-4:IFN-gamma) x 100 ratio (P < 0.0001) and production of T. gondii-specific IgE in six out of 13 children showing serological rebound. These results suggest a role of Th2 cytokines in destabilization of congenital toxoplasmosis and perhaps in local reactivation of the parasite.
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