ArticleProceedings of the National Academy of Sciences of the United States of America1999
Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 120 citations in OpenAlex.
- TBX3 shapes an immunosuppressive microenvironment and induces immunotherapy resistance.Theranostics · 2025Article
- Context-dependent T-BOX transcription factor family: from biology to targeted therapy.Cell communication and signaling : CCS · 2024Review
- TBX3 stimulates proliferation and stem cell self-renewal in bladder carcinoma.Histology and histopathology · 2023Article
- Establishment of the TBX-code reveals aberrantly activated T-box gene TBX3 in Hodgkin lymphoma.PloS one · 2021Article
- T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygotic Genome Activation.Cell reports · 2019Article
- TBX3 represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma.Oncogenesis · 2019Article
- Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.Cellular and molecular life sciences : CMLS · 2019Article
- Transcriptome analysis of regeneration during Xenopus laevis experimental twinning.The International journal of developmental biology · 2019Article
- TBX5: A Key Regulator of Heart Development.Current topics in developmental biology · 2017Review
- Function of the C. elegans T-box factor TBX-2 depends on interaction with the UNC-37/Groucho corepressor.Developmental biology · 2016Article
- Putative Breast Cancer Driver Mutations in TBX3 Cause Impaired Transcriptional Repression.Frontiers in oncology · 2015Article
- TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells.International journal of cancer · 2014Article
- The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis.The Journal of biological chemistry · 2014Article
- Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeat.PloS one · 2014Article
- Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells.Scientific reports · 2013Article
- The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer.Journal of mammary gland biology and neoplasia · 2013Review
- The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs.Journal of virology · 2013Article
- Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma.BMC cancer · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
T box (Tbx) genes are a family of developmental regulators with more than 20 members recently identified in invertebrates and vertebrates. Mutations in Tbx genes have been found to cause several human diseases. Our understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/Brachyury, which is a transcription activator. We previously discovered ET, a Tbx gene expressed in Xenopus embryos. We report here that ET is an ortholog of the human Tbx3 and that ET is a repressor of basal and activated transcription. Functional dissection of the ET protein reveals a novel transcription-repression domain highly conserved among ET, human TBX3, and TBX2. These results reveal a new transcription repressor domain, show the existence of a subfamily of transcription repressors in the Tbx superfamily, and provide a basis for understanding etiology of diseases caused by Tbx3 mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.