ArticleProceedings of the National Academy of Sciences of the United States of America1999
A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- CaAdvances in experimental medicine and biology · 2023Article
- Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.PloS one · 2011Article
- Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C).Molecular and cellular biology · 2011Article
- Proteomics of industrial fungi: trends and insights for biotechnology.Applied microbiology and biotechnology · 2011Review
- A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.Nature cell biology · 2010Article
- Retromer.Current opinion in cell biology · 2008Review
- Quantification of polarized trafficking of transferrin and comparison with bulk membrane transport in hepatic cells.The Biochemical journal · 2006Article
- Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins.The Journal of cell biology · 2004Article
- Heterotrimeric G protein subunits are located on rat liver endosomes.BMC physiology · 2004Article
- Rate and extent of phagocytosis in macrophages lacking vamp3.Journal of leukocyte biology · 2002Article
- A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane.The EMBO journal · 2002Article
- Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes.Molecular biology of the cell · 2002Article
- A myosin I is involved in membrane recycling from early endosomes.The Journal of cell biology · 2000Article
- The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components.Molecular biology of the cell · 2000Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We previously have isolated an endosomal fraction from rat liver, termed receptor-recycling compartment (RRC), which is highly enriched in recycling receptors and in the transcytotic polymeric Ig receptor (pIgR). We now have analyzed the RRC fraction by immunoisolation and found that no uniquely transcytotic elements were present, because recycling receptors and the pIgR were coisolated on the same elements. In addition, RRC was very rich in proteins previously shown to be associated with recycling endosomes, such as rab 11, cellubrevin, and endobrevin, but relatively poor in early endosome antigen 1. As RRC contains mainly tubules and small vesicles, our results indicate that it is enriched in elements of a tubular endosomal compartment involved in receptor sorting. Biochemical analysis showed that the density of recycling receptors and transcytotic pIgR in RRC membranes was similar to that in early endosome membranes. This observation supports the idea that increasing membrane surface area by endosome tubulation is the main mechanism to ensure efficient receptor sorting and, at the same time, locates RRC in a common step of the endocytotic system before final receptor segregation into distinct recycling and transcytotic pathways.
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