ArticleBritish journal of cancer1999
Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 132 citations in OpenAlex.
- Psychologic Stress Drives Progression of Malignant Tumors via DRD2/HIF1α Signaling.Cancer research · 2021Article
- Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions.Redox biology · 2021Article
- Review
- Review
- Clinical implications of ALDH1A1 and ALDH1A3 mRNA expression in melanoma subtypes.Chemico-biological interactions · 2019Article
- Phosphorylated Akt Protein at Ser473 Enables HeLa Cells to Tolerate Nutrient-Deprived ConditionsAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Long-Lived Epidermal Cancer-Initiating Cells.International journal of molecular sciences · 2017Review
- The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism.Cancer letters · 2015Review
- Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression.PloS one · 2015Article
- Is cancer a metabolic disease?The American journal of pathology · 2014Review
- Molecular mechanisms involved in tumor repopulation after radiotherapy.Translational cancer research · 2013Article
- A microfabricated platform for establishing oxygen gradients in 3-D constructs.Biomedical microdevices · 2013Article
- Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells.Journal of cellular and molecular medicine · 2013Article
- Vascular density and endothelial cell expression of integrin alpha v beta 3 and E-selectin in murine tumours.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Article
- Effect of culture at low oxygen tension on the expression of heat shock proteins in a panel of melanoma cell lines.PloS one · 2012Article
- Snail1 mediates hypoxia-induced melanoma progression.The American journal of pathology · 2011Article
- Antimetastatic activity of MONCPT in preclinical melanoma mice model.Investigational new drugs · 2010Article
- HIF-1α Promotes A Hypoxia-Independent Cell Migration.The open biology journal · 2010Article
- Revisiting the seed and soil in cancer metastasis.The international journal of biochemistry & cell biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumour cells exposed to hypoxia have been shown to up-regulate the expression of vascular endothelial growth factor (VEGF). The purpose of the present work was to investigate whether hypoxia-induced VEGF up-regulation can result in increased metastatic efficiency of human melanoma cells. Two melanoma lines, one showing high (A-07) and the other showing low (D-12) VEGF secretion under aerobic conditions, were included in the study. Cell cultures were exposed to hypoxia (oxygen concentrations < 10 ppm) in vitro and metastatic efficiency, i.e. lung colonization efficiency, as well as transplantability and angiogenic potential were assessed in BALB/c-nu/nu mice Both cell lines showed significantly increased VEGF secretion under hypoxic conditions as measured by enzyme-linked immunosorbent assay The D-12 cells showed increased metastatic efficiency, transplantability and angiogenic potential following exposure to hypoxia. The metastatic efficiency increased with the duration of the hypoxia treatment and decreased with the time after reoxygenation. The A-07 cells on the other hand showed unchanged metastatic efficiency, transplantability and angiogenic potential following exposure to hypoxia. Both cell lines showed significantly decreased metastatic efficiency and angiogenic potential in mice treated with neutralizing antibody against VEGF. These results suggest that (a) VEGF is a limiting factor for the rate of angiogenesis in low but not in high VEGF-expressing melanomas under normoxic conditions and (b) transient hypoxia might promote the development of metastases in low VEGF-expressing melanomas by upregulating the expression of VEGF and hence enhancing the angiogenic potential of the tumour cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.