ReviewImmunologic research1999
Murine mercury-induced autoimmunity: a model of chemically related autoimmunity in humans.
Review in Immunologic research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 92 citations in OpenAlex.
- Mercury intoxication disrupts tonic signaling in B cells, and may promote autoimmunity due to abnormal phosphorylation of STIM-1 and other autoimmunity risk associated phosphoproteins involved in BCR signaling.Toxicology and applied pharmacology · 2023Article
- Low level exposure to inorganic mercury interferes with B cell receptor signaling in transitional type 1 B cells.Toxicology and applied pharmacology · 2017Article
- Predictors and immunological correlates of sublethal mercury exposure in vampire bats.Royal Society open science · 2017Article
- Dietary n-3 PUFAs augment caspase 8 activation in Staphylococcal aureus enterotoxin B stimulated T-cells.Toxicology and applied pharmacology · 2016Article
- Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004.Environmental health perspectives · 2016Article
- An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis.Journal of immunology research · 2015Article
- A systems toxicology approach identifies Lyn as a key signaling phosphoprotein modulated by mercury in a B lymphocyte cell model.Toxicology and applied pharmacology · 2014Article
- Thimerosal-induced apoptosis in mouse C2C12 myoblast cells occurs through suppression of the PI3K/Akt/survivin pathway.PloS one · 2012Article
- Anti-metallothionein IgG and levels of metallothionein in autistic children with GI disease.Drug, healthcare and patient safety · 2009Article
- Regulatory roles for NKT cell ligands in environmentally induced autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The cysteine-cluster motif of c-Src: its role for the heavy metal-mediated activation of kinase.Cancer science · 2008Article
- Exposure to inorganic mercury in vivo attenuates extrinsic apoptotic signaling in Staphylococcal aureus enterotoxin B stimulated T-cells.Toxicology and applied pharmacology · 2007Article
- Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways.Clinical and experimental immunology · 2007Article
- Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study.Environmental health : a global access science source · 2007Article
- Blood mercury reporting in NHANES: identifying Asian, Pacific Islander, Native American, and multiracial groups.Environmental health perspectives · 2006Article
- Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced autoimmunity and exacerbates such autoimmunity in susceptible mice.Clinical and experimental immunology · 2005Article
- Article
- Associations between plasma DDE levels and immunologic measures in African-American farmers in North Carolina.Environmental health perspectives · 2004Article
- Mercury-induced autoimmunity in mice.Environmental health perspectives · 2002Article
- Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway.Genes and immunity · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Human exposure to certain compounds or therapeutic drugs can result in the development of an autoimmune syndrome. Mercury (Hg) induced autoimmunity is one of the few animal models in which administration of a chemical induces a specific loss of tolerance to self-antigens. After receiving subtoxic doses of Hg or other heavy metals, susceptible mouse strains rapidly develop highly specific antibodies to nucleolar antigens. In addition, these animals display a general activation of the immune system, especially pronounced for the Th2 subset and a transient glomerulonephritis with immunoglobulin deposits. Like many human autoimmune diseases, this syndrome is associated with the expression of susceptible major histocompatibility complex (MHC) class II genes. In this article, we review the essential features of this model, and we discuss the putative mechanisms by which Hg creates such a severe immune dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.