ArticleBiophysical journal1999
Model of intercellular calcium oscillations in hepatocytes: synchronization of heterogeneous cells.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 156 citations in OpenAlex.
- Hepatic neurons and metabolically induced liver dysfunction.Nature reviews. Endocrinology · 2026Review
- Modeling IPBiophysical journal · 2023Article
- Engaging biological oscillators through second messenger pathways permits emergence of a robust gastric slow-wave during peristalsis.PLoS computational biology · 2021Article
- Cardiomyocyte Calcium Ion Oscillations-Lessons From Physics.Frontiers in physiology · 2020Review
- Three dimensional coupled reaction-diffusion modeling of calcium and inositol 1,4,5-trisphosphate dynamics in cardiomyocytes.RSC advances · 2019Article
- Computational Analysis of Insulin-Glucagon Signalling Network: Implications of Bistability to Metabolic Homeostasis and Disease states.Scientific reports · 2019Article
- Calcium as a signal integrator in developing epithelial tissues.Physical biology · 2018Review
- A mathematical model of calcium dynamics in HSY cells.PLoS computational biology · 2017Article
- The Effect of Gap Junctional Coupling on the Spatiotemporal Patterns of Ca2+ Signals and the Harmonization of Ca2+-Related Cellular Responses.PLoS computational biology · 2016Article
- Computational Modeling of Spatiotemporal Ca(2+) Signal Propagation Along Hepatocyte Cords.IEEE transactions on bio-medical engineering · 2016Article
- Intercellular Ca(2+) waves: mechanisms and function.Physiological reviews · 2012Review
- A composite computational model of liver glucose homeostasis. I. Building the composite model.Journal of the Royal Society, Interface · 2012Article
- Mechanisms of propagation of intercellular calcium waves in arterial smooth muscle cells.Biophysical journal · 2010Article
- Jensen's inequality as a tool for explaining the effect of oscillations on the average cytosolic calcium concentration.Theory in biosciences = Theorie in den Biowissenschaften · 2010Article
- Effectors of the frequency of calcium oscillations in HEK-293 cells: wavelet analysis and a computer model.European biophysics journal : EBJ · 2009Article
- Connexin specificity of second messenger permeation: real numbers at last.The Journal of general physiology · 2008Article
- Equality of average and steady-state levels in some nonlinear models of biological oscillations.Theory in biosciences = Theorie in den Biowissenschaften · 2008Article
- Integrating biosystem models using waveform relaxation.EURASIP journal on bioinformatics & systems biology · 2008Article
- Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment.Biophysical journal · 2007Article
- Diffusion of calcium and metabolites in pancreatic islets: killing oscillations with a pitchfork.Biophysical journal · 2006Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocytes respond with repetitive cytosolic calcium spikes to stimulation by vasopressin and noradrenalin. In the intact liver, calcium oscillations occur in a synchronized fashion as periodic waves across whole liver lobules, but the mechanism of intercellular coupling remains unclear. Recently, it has been shown that individual hepatocytes can have very different intrinsic oscillation frequencies but become phase-locked when coupled by gap junctions. We investigate the gap junction hypothesis for intercellular synchronization by means of a mathematical model. It is shown that junctional calcium fluxes are effective in synchronizing calcium oscillations in coupled hepatocytes. An experimentally testable estimate is given for the junctional coupling coefficient required; it mainly depends on the degree of heterogeneity between cells. Intercellular synchronization by junctional calcium diffusion may occur also in other cell types exhibiting calcium-activated calcium release through InsP(3) receptors, if the gap junctional coupling is strong enough and the InsP(3) receptors are sufficiently sensitized by InsP(3).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.