ArticleJournal of bacteriology1999
Analysis of BvgA activation of the pertactin gene promoter in Bordetella pertussis.
Article in Journal of bacteriology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Lonidamine, a Novel Modulator for the BvgAS System of Bordetella Species.Microbiology and immunology · 2025Article
- Combined transcriptomic and ChIPseq analyses of themSystems · 2024Article
- Multiple weak interactions between BvgA~P and ptx promoter DNA strongly activate transcription of pertussis toxin genes in Bordetella pertussis.PLoS pathogens · 2020Article
- Activation of Bvg-Repressed Genes in Bordetella pertussis by RisA Requires Cross Talk from Noncooperonic Histidine Kinase RisK.Journal of bacteriology · 2017Article
- Intracellular disassembly and activity of pertussis toxin require interaction with ATP.Pathogens and disease · 2016Article
- Rapid increase in pertactin-deficient Bordetella pertussis isolates, Australia.Emerging infectious diseases · 2014Article
- The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA.Microbiology (Reading, England) · 2012Review
- BpsR modulates Bordetella biofilm formation by negatively regulating the expression of the Bps polysaccharide.Journal of bacteriology · 2012Article
- Novel architectural features of Bordetella pertussis fimbrial subunit promoters and their activation by the global virulence regulator BvgA.Molecular microbiology · 2010Article
- Microarray and functional analysis of growth phase-dependent gene regulation in Bordetella bronchiseptica.Infection and immunity · 2009Article
- Differential Bvg phase-dependent regulation and combinatorial role in pathogenesis of two Bordetella paralogs, BipA and BcfA.Journal of bacteriology · 2007Article
- Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis.Journal of bacteriology · 2005Article
- Acid-induced activation of the urease promoters is mediated directly by the ArsRS two-component system of Helicobacter pylori.Infection and immunity · 2005Article
- Bordetella pertussis risA, but not risS, is required for maximal expression of Bvg-repressed genes.Infection and immunity · 2005Article
- Mode of action of the Bordetella BvgA protein: transcriptional activation and repression of the Bordetella bronchiseptica bipA promoter.Journal of bacteriology · 2005Article
- Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells.BMC microbiology · 2005Article
- The BvgAS signal transduction system regulates biofilm development in Bordetella.Journal of bacteriology · 2005Article
- Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein.Infection and immunity · 2004Article
- Analysis of bvgR expression in Bordetella pertussis.Journal of bacteriology · 2003Article
- Pertussis toxin plays an early role in respiratory tract colonization by Bordetella pertussis.Infection and immunity · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Bordetella pertussis, the causative agent of whooping cough, regulates expression of its virulence factors via a two-component signal transduction system encoded by the bvg regulatory locus. It has been shown by activation kinetics that several of the virulence factors are differentially regulated. fha is transcribed at 10 min following an inducing signal, while ptx is not transcribed until 2 to 4 h after the inducing signal. We present data indicating that prn is transcribed at 1 h, an intermediate time compared to those of fha and ptx. We have identified cis-acting sequences necessary for expression of prn in B. pertussis by using prn-lac fusions containing alterations in the sequence upstream of the prn open reading frame. In vitro transcription and DNase I footprinting analyses provided evidence to support our hypothesis that BvgA binds to this sequence upstream of prn to activate transcription from the promoter. Our genetic data indicate that the region critical for prn activation extends upstream to position -84. However, these data do not support the location of the prn transcription start site as previously published. We used a number of methods, including prn-lac fusions, reverse transcriptase PCR, and 5' rapid amplification of cDNA ends, to localize and identify the bvg-dependent 5' end of the prn transcript to the cytosine at -125 with respect to the published start site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.