Evidence map›Paper›PMID 10461349›Full record

ReviewThe Yale journal of biology and medicine

Physiology of the ECL cells.

R Håkanson, D Chen, E Lindström, P Norlén, M Björkqvist, D Lehto-Axtelius

Open access · greenAbstract readReviewComment
PubMed Full text at PMC
In one paragraph

Review in The Yale journal of biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Mechanism of gastric bypass-induced body weight loss: one-year follow-up after micro-gastric bypass in rats.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2006
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

R HåkansonDepartment of Pharmacology, University of Lund, Sweden.
D Chen
E Lindström
P Norlén
M Björkqvist
D Lehto-Axtelius
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enterochromaffin-like (ECL) cells of the oxyntic mucosa (fundus) of the stomach produce, store and secrete histamine, chromogranin A-derived peptides such as pancreastatin, and an unanticipated but as yet unidentified peptide hormone. The cells are stimulated by gastrin and pituitary adenylate cyclase activating peptide and suppressed by somatostatin and galanin. Choline esters and histamine seem to be without effect on ECL cell secretion. The existence of a gastrin-ECL cell axis not only explains how gastrin stimulates acid secretion but also may help to explore the functional significance of the ECL cells with respect to the nature and bioactivity of its peptide hormone. From the results of studies of gastrectomized/fundectomized and gastrin-treated rats, it has been speculated that the anticipated ECL-cell peptide hormone acts on bone metabolism.

Indexed as

AnimalsChromogranin AEnterochromaffin-like CellsGastrinsHistamineNeuropeptidesNeurotransmitter AgentsPancreatic HormonesPituitary Adenylate Cyclase-Activating PolypeptideRatsSomatostatinVasoactive Intestinal PeptideAdcyap1 protein, ratChromogranin AGastrinsHistamineNeuropeptidesNeurotransmitter AgentspancreastatinPancreatic HormonesPituitary Adenylate Cyclase-Activating PolypeptideSomatostatinVasoactive Intestinal Peptide

Identifiers

PMID10461349
PMCPMC2578978
OpenAlexW2427235042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.