ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Evidence of an agrin receptor in cortical neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 59 citations in OpenAlex.
- Extracellular matrix and synapse formation.Bioscience reports · 2023Article
- The role of agrin in synaptic development, plasticity and signaling in the central nervous system.Neurochemistry international · 2012Review
- Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities.The Journal of biological chemistry · 2010Article
- A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation.Neurobiology of disease · 2009Article
- Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction.The Journal of biological chemistry · 2009Article
- Transmembrane form agrin-induced process formation requires lipid rafts and the activation of Fyn and MAPK.The Journal of biological chemistry · 2009Article
- Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- HIV-1-infected blood mononuclear cells form an integrin- and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer.Molecular biology of the cell · 2005Article
- Fast synaptic currents in Drosophila mushroom body Kenyon cells are mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors and picrotoxin-sensitive GABA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons.The Journal of cell biology · 2003Article
- Agrin plays an organizing role in the formation of sympathetic synapses.The Journal of cell biology · 2002Article
- Agrin differentially regulates the rates of axonal and dendritic elongation in cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Agrin controls synaptic differentiation in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Agrin isoforms with distinct amino termini: differential expression, localization, and function.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Agrin plays a key role in directing the differentiation of the vertebrate neuromuscular junction. Understanding agrin function at the neuromuscular junction has come via molecular genetic analyses of agrin as well as identification of its receptor and associated signal transduction pathways. Agrin is also expressed by many populations of neurons in brain, but its role remains unknown. Here we show, in cultured cortical neurons, that agrin induces expression of the immediate early gene c-fos in a concentration-dependent and saturable manner, as expected for a signal transduction pathway activated by a cell surface receptor. Agrin is active in cortical neurons at picomolar concentrations, is Ca(2+) dependent, and is inhibited by heparin and staurosporine. Despite marked differences in acetylcholine receptor (AChR)-clustering activity, all alternatively spliced forms of agrin are equally potent inducers of c-fos in cortical neurons. A similar, isoform-independent response to agrin was also observed in cultures prepared from the hippocampus and cerebellum. Only agrin with high AChR-clustering activity was effective in cultured muscle, whereas non-neuronal cells were agrin insensitive. Although consistent with a receptor tyrosine kinase model similar to the muscle-specific kinase-myotube-associated specificity component complex in muscle, our data suggest that CNS neurons express a unique agrin receptor. Evidence that neuronal signal transduction is mediated via an increase in intracellular Ca(2+) means that agrin is well situated to influence important Ca(2+)-dependent functions in brain, including neuronal growth, differentiation, and adaptive changes in gene expression associated with synaptic remodeling.
Indexed as
Identifiers
10460245PMC6782495W2171035480What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.