ArticleThe Journal of physiology1999
Electrophysiological properties of electrical synapses between rat sympathetic preganglionic neurones in vitro.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Intersegmental coordination of the central pattern generator via interleaved electrical and chemical synapses in zebrafish spinal cord.Journal of computational neuroscience · 2023Article
- Brainstem noradrenergic neurons: Identifying a hub at the intersection of cognition, motility, and skeletal muscle regulation.Acta physiologica (Oxford, England) · 2022Review
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity.Frontiers in physiology · 2020Review
- Dye-coupling between neonatal spinal motoneurons and interneurons revealed by prolonged back-filling of a ventral root with a low molecular weight tracer in the mouse.Scientific reports · 2019Article
- Active integration of glutamatergic input to the inferior olive generates bidirectional postsynaptic potentials.The Journal of physiology · 2017Article
- Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration: a whole cell recording study in situ.The Journal of physiology · 2014Article
- Rectifying electrical synapses can affect the influence of synaptic modulation on output pattern robustness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat.Journal of biomedical science · 2012Article
- GABA(B) Mediated Regulation of Sympathetic Preganglionic Neurons: Pre- and Postsynaptic Sites of Action.Frontiers in neurology · 2010Article
- Pseudorabies virus infection alters neuronal activity and connectivity in vitro.PLoS pathogens · 2009Article
- Locomotor rhythm maintenance: electrical coupling among premotor excitatory interneurons in the brainstem and spinal cord of young Xenopus tadpoles.The Journal of physiology · 2009Article
- Immunohistochemical detection of connexin36 in sympathetic preganglionic and somatic motoneurons in the adult rat.Autonomic neuroscience : basic & clinical · 2008Article
- Electrical coupling between locomotor-related excitatory interneurons in the mammalian spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Physiological properties of rod photoreceptor electrical coupling in the tiger salamander retina.The Journal of physiology · 2005Article
- GABAergic neurons in the central region of the spinal cord: a novel substrate for sympathetic inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Dendrodendritic electrical synapses between mammalian retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones.The Journal of physiology · 2003Article
- Characterization of the circuits that generate spontaneous episodes of activity in the early embryonic mouse spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Electrical synapses mediate signal transmission in the rod pathway of the mammalian retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
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Authors and funding
3 authors.
Funding
Abstract
1. The electrophysiological properties of electrical synaptic transmission between sympathetic preganglionic neurones (SPNs) in slices of rat spinal cord were investigated using simultaneous dual-electrode patch-clamp recordings. Electrotonic coupling was directly demonstrated between 21 pairs of SPNs. 2. Coupling coefficients determined from the steady-state response of both neurones to current steps injected into either neurone ranged from 0. 02 to 0.48 (0.18 +/- 0.02, mean +/- s.e.m.). Synapses were bidirectional and symmetrical for the majority of connections with coupling coefficients similar in either direction. Asymmetrical coupling between a minority of cell pairs was due to differences in passive neuronal properties rather than rectification of the synaptic conductances. 3. Action potentials were manifest in adjoining cells as biphasic electrical postsynaptic potentials (ePSPs), composed of a rapid depolarising component followed by a more prolonged hyperpolarisation with amplitudes of 1.2 +/- 0.2 and 2.1 +/- 0.6 mV, respectively. 4. Postsynaptic potentials resembled low-pass filtered presynaptic spikes with frequency dependence determined by the junctional conductance and postsynaptic membrane properties. Increases in presynaptic action potential frequency caused attenuation of the hyperpolarising component of the ePSP that was attributed to shorter duration presynaptic spikes being more markedly filtered. 5. Synchronisation of spontaneous action potentials between electrotonically coupled neurones was driven by subthreshold membrane potential activity resembling repetitive ePSPs. Synchronous spike firing in previously silent neurones could be driven by suprathreshold ePSPs induced by suprathreshold depolarisation of a single adjoining neurone. 6. These data characterise reliable communication of sub- and suprathreshold activity by electrical synapses enabling synchronised SPN firing which may contribute to generation of coherent sympathetic rhythms and promote summation of inputs to postganglionic neurones.
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