ArticleInfection and immunity1999
Identification of abundantly expressed novel and conserved genes from the infective larval stage of Toxocara canis by an expressed sequence tag strategy.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 89 citations in OpenAlex.
- Antigenic Proteins from the Excretory-Secretory Products of Toxocara canis Larvae and Evaluation of Their Potential for Immunodiagnostics of Larval Toxocarosis.Acta parasitologica · 2022Article
- Jingmenviruses: Ubiquitous, understudied, segmented flavi-like viruses.Frontiers in microbiology · 2022Review
- Article
- Twenty-five-year research progress in hookworm excretory/secretory products.Parasites & vectors · 2020Review
- Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants.PLoS pathogens · 2018Review
- Comparative analysis of pre- and post-parasitic transcriptomes and mining pioneer effectors ofCell & bioscience · 2017Article
- Divergent Viruses Discovered in Arthropods and Vertebrates Revise the Evolutionary History of the Flaviviridae and Related Viruses.Journal of virology · 2016Article
- Toxocara canis mucins among other excretory-secretory antigens induce in vitro secretion of cytokines by mouse splenocytes.Parasitology research · 2015Article
- Development of a Luminex Bead Based Assay for Diagnosis of Toxocariasis Using Recombinant Antigens Tc-CTL-1 and Tc-TES-26.PLoS neglected tropical diseases · 2015Article
- A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Toxocara canis: molecular basis of immune recognition and evasion.Veterinary parasitology · 2013Article
- Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins.Journal of proteomics · 2011Article
- ES proteins analysis of Angiostrongylus cantonensis: products of the potential parasitism genes?Parasitology research · 2010Article
- C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis.Parasitology international · 2009Article
- A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells.PLoS pathogens · 2009Article
- Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity.Molecular and biochemical parasitology · 2009Review
- Toxocariasis: America's most common neglected infection of poverty and a helminthiasis of global importance?PLoS neglected tropical diseases · 2009Article
- Expressed sequence tags of Trichinella spiralis muscle stage larvae.The Korean journal of parasitology · 2008Article
- Immune response studies with Wuchereria bancrofti vespid allergen homologue (WbVAH) in human lymphatic filariasis.Parasitology research · 2007Article
- Molecular cloning and characterization of a C-type lectin from Ancylostoma ceylanicum: evidence for a role in hookworm reproductive physiology.Molecular and biochemical parasitology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Larvae of Toxocara canis, a nematode parasite of dogs, infect humans, causing visceral and ocular larva migrans. In noncanid hosts, larvae neither grow nor differentiate but endure in a state of arrested development. Reasoning that parasite protein production is orientated to immune evasion, we undertook a random sequencing project from a larval cDNA library to characterize the most highly expressed transcripts. In all, 266 clones were sequenced, most from both 3' and 5' ends, and similarity searches against GenBank protein and dbEST nucleotide databases were conducted. Cluster analyses showed that 128 distinct gene products had been found, all but 3 of which represented newly identified genes. Ninety-five genes were represented by a single clone, but seven transcripts were present at high frequencies, each composing >2% of all clones sequenced. These high-abundance transcripts include a mucin and a C-type lectin, which are both major excretory-secretory antigens released by parasites. Four highly expressed novel gene transcripts, termed ant (abundant novel transcript) genes, were found. Together, these four genes comprised 18% of all cDNA clones isolated, but no similar sequences occur in the Caenorhabditis elegans genome. While the coding regions of the four genes are dissimilar, their 3' untranslated tracts have significant homology in nucleotide sequence. The discovery of these abundant, parasite-specific genes of newly identified lectins and mucins, as well as a range of conserved and novel proteins, provides defined candidates for future analysis of the molecular basis of immune evasion by T. canis.
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