ArticleInfection and immunity1999
Control of white-opaque phenotypic switching in Candida albicans by the Efg1p morphogenetic regulator.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
91 citing papers in PubMed, 164 citations in OpenAlex.
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- Research advances and public health strategies in China on WHO priority fungal pathogens.Mycology · 2025Review
- Histone-like transcription factor Hfl1p inVirulence · 2024Article
- The rod cell, a small form ofActa biochimica et biophysica Sinica · 2024Article
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Structure and interactions of prion-like domains in transcription factor Efg1 phase separation.Biophysical journal · 2024Article
- An epigenetic change in a moth is generated by temperature and transmitted to many subsequent generations mediated by RNA.PloS one · 2024Article
- Strain and temperature dependent aggregation ofCell surface (Amsterdam, Netherlands) · 2023Article
- The defective gut colonization ofVirulence · 2023Article
- Structure and position-specific interactions of prion-like domains in transcription factor Efg1 phase separation.bioRxiv : the preprint server for biology · 2023Article
- Article
- Cell-type memory in a single-cell eukaryote requires the continuous presence of a specific transcription regulator.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Farnesol and phosphorylation of the transcriptional regulator Efg1 affect Candida albicans white-opaque switching rates.PloS one · 2023Article
- Overexpression of the White Opaque Switching Master Regulator Wor1 Alters Lipid Metabolism and Mitochondrial Function inJournal of fungi (Basel, Switzerland) · 2022Article
- Overexpression approaches to advance understanding of Candida albicans.Molecular microbiology · 2022Review
- Review
- The Glyoxylate Cycle Is Involved in White-Opaque Switching inJournal of fungi (Basel, Switzerland) · 2021Article
- Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans.Antimicrobial agents and chemotherapy · 2021Article
- A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans.Nature communications · 2020Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotypic switching in Candida albicans spontaneously generates different cellular morphologies and is manifested in strain WO-1 by the reversible switching between the white and opaque phenotypes. We present evidence that phenotypic switching is regulated by the Efg1 protein, which is known as an essential element of hyphal development (dimorphism). Firstly, EFG1 is expressed specifically in cells of the white but not the opaque phenotype. During mass conversion from the opaque to the white phenotype, the EFG1 transcript level correlates with competence of switching of opaque cells to the white form. Secondly, overexpression of EFG1 by a PCK1p-EFG1 fusion forces opaque-phase cells to switch to the white form with a high level of efficiency. Thirdly, low-level expression of EFG1 in strain CAI-8 generates a cellular phenotype similar to that of opaque cells in that cells bud as short rods, which cannot be induced to form hyphae in standard conditions; such cells (unlike authentic opaque cells) lack typical surface "pimples." Importantly, the opaque-specific OP4 transcript is induced in the opaque-like cells generated by strain CAI8 as a response to low-level expression of EFG1. The results suggest that high EFG1 expression levels induce and maintain the white cell form while low EFG1 expression levels induce and maintain the opaque cell form. It is proposed that changes in EFG1 expression determine or contribute to phenotypic switching events in C. albicans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.