ArticleInfection and immunity1999
Role of tumor necrosis factor alpha, interleukin-1beta, and interleukin-6 in a mouse model of group B streptococcal arthritis.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Health functions and related molecular mechanisms ofHeliyon · 2023Review
- Group B Streptococci Induce Proinflammatory Responses via a Protein Kinase D1-Dependent Pathway.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients.Journal of immunology research · 2017Article
- Inflammatory cytokines in diabetic nephropathy.Journal of diabetes research · 2015Review
- IFN-γ-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis.Journal of leukocyte biology · 2012Article
- Potential role of fibroblast-like synoviocytes in joint damage induced by Brucella abortus infection through production and induction of matrix metalloproteinases.Infection and immunity · 2011Article
- Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease.Infection and immunity · 2009Article
- IL-4 deficiency decreases mortality but increases severity of arthritis in experimental group B Streptococcus infection.Mediators of inflammation · 2009Article
- Glucuronoxylomannan, the major capsular polysaccharide of Cryptococcus neoformans, inhibits the progression of group B streptococcal arthritis.Infection and immunity · 2004Article
- Inhibition of nitric oxide synthase exacerbates group B streptococcus sepsis and arthritis in mice.Infection and immunity · 2004Article
- Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand.Infection and immunity · 2003Article
- Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells.Infection and immunity · 2003Article
- Regulatory role of interleukin-10 in experimental group B streptococcal arthritis.Infection and immunity · 2002Article
- Cytokine modulation of liver annexin 1 expression during experimental endotoxemia.The American journal of pathology · 2001Article
- Ratio of local to systemic chemokine concentrations regulates neutrophil recruitment.The American journal of pathology · 2001Article
- Severity of group B streptococcal arthritis in selected strains of laboratory mice.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravenous inoculation of CD1 mice with 10(7) CFU of type IV group B Streptococcus (GBS IV) results in a high incidence of diffuse septic arthritis. In this study the roles of tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 in articular pathology were evaluated. Cytokine levels were quantified in the serum and joints by enzyme-linked immunosorbent assay in mice injected with GBS IV and tested or not tested with pentoxifylline (PTF), a methylxanthine that affects cytokine production. PTF was administered intraperitoneally at a dose of 1 mg/mouse (50 mg/kg of body weight) 1 h after GBS infection and then at 24-h intervals for 4 days. High levels of IL-1beta and IL-6, but not TNF-alpha, were detected in the joints of mice injected with GBS IV from 5 to 15 days after infection, when articular lesions were most frequent and severe. IL-1beta and IL-6 concentrations in the joints significantly (P < 0.001) exceeded those detected in the serum, confirming a strong local production. PTF treatment resulted in a strong reduction of cytokine production and in a marked decrease in both the incidence and severity of arthritis. Inoculation of exogenous murine recombinant IL-1beta or IL-6 in mice treated with GBS IV plus PTF resulted in an incidence and severity of articular lesions similar to those obtained with inoculation of GBS IV alone. No significant effect was obtained with TNF-alpha administration. These data show a strong involvement of IL-1beta and IL-6, but not TNF-alpha, in the pathogenesis of GBS arthritis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.