ArticleGene therapy1999
Temporally regulated expression patterns following in utero adenovirus-mediated gene transfer.
Article in Gene therapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Article
- Recent Genome-Editing Approaches toward Post-Implanted Fetuses in Mice.Biotech (Basel (Switzerland)) · 2023Review
- Transplacental Gene Delivery (TPGD) as a Noninvasive Tool for Fetal Gene Manipulation in Mice.International journal of molecular sciences · 2019Review
- In utero lung gene transfer using adeno-associated viral and lentiviral vectors in mice.Human gene therapy methods · 2014Article
- Kidney-specific expression of GFP by in-utero delivery of pseudotyped adeno-associated virus 9.Molecular therapy. Methods & clinical development · 2014Article
- Successful gene therapy in utero for lethal murine hypophosphatasia.Human gene therapy · 2012Article
- A mouse model of in utero transplantation.Journal of visualized experiments : JoVE · 2011Article
- The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors.Gene therapy · 2010Article
- Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevance.Endocrinology · 2007Article
- Fetal gene therapy of alpha-thalassemia in a mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells.Blood · 2007Article
- High resolution ultrasound-guided microinjection for interventional studies of early embryonic and placental development in vivo in mice.BMC developmental biology · 2006Article
- Transplacental RNAi: deciphering gene function in the postimplantation-staged embryo.Journal of biomedicine & biotechnology · 2006Article
- Comparison of high-capacity and first-generation adenoviral vector gene delivery to murine muscle in utero.Gene therapy · 2005Article
- Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.Gene therapy · 2003Article
- Possible mechanism of gene transfer into early to mid-gestational mouse fetuses by tail vein injection.Gene therapy · 2002Article
- Adenovirus-mediated prenatal gene transfer to murine central nervous system.Gene therapy · 2002Article
- Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Long-term gene transfer to mouse fetuses with recombinant adenovirus and adeno-associated virus (AAV) vectors.Gene therapy · 2000Article
- Fetal gene therapy.Gene therapy · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Developmental patterns of gene expression were determined following intravascular administration of adenovirus in utero, during sequential stages of murine development. Replication-deficient adenovirus (AdCMV.LacZ) was injected into yolk sac vessels of mouse embryos 12, 13, 15 and 18 days post-conception (d.p.c.). beta-Galactosidase (beta-gal) expression was evaluated 24-48 h after injection, at birth, and 5 weeks following normal delivery. Gene expression was detected in myocardial cells, endothelial cells of heart, lung, kidney, adrenal, gut, and in hepatocytes. The patterns of expression were distinct for each stage of virus administration and time-point of analysis. Intensity of individual organ expression varied with injection time-point, with the largest number of organs express- ing the transgene when embryos were injected at 15 d.p.c. beta-Gal activity was detected in only a subset of cells expressing the murine coxsackievirus and adenovirus receptor (CAR), indicating factors other than receptor distribution were responsible for the pattern of transgene expression observed. These studies begin to define critical parameters affecting intravascular gene delivery in utero and indicate that intrinsic developmental regulatory mechanisms may control exogenous gene expression. Intravenous administration of adenovirus provides a unique approach for in utero gene transduction and will be a useful adjunct in evaluating genes which have early lethal mutations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.