ArticleBritish journal of pharmacology1999
Pharmacological characterization of Ca2+ entry channels in endothelin-1-induced contraction of rat aorta using LOE 908 and SK&F 96365.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 57 citations in OpenAlex.
- Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer.Frontiers in pharmacology · 2021Review
- The interdependence of endothelin-1 and calcium: a review.Clinical science (London, England : 1979) · 2010Review
- New insights in the contribution of voltage-gated Na(v) channels to rat aorta contraction.PloS one · 2009Article
- Rat strain differences in pulmonary artery smooth muscle Ca(2+) entry following chronic hypoxia.Microcirculation (New York, N.Y. : 1994) · 2009Article
- Endothelin ET(B) receptors in arteries and veins: multiple actions in the vein.The Journal of pharmacology and experimental therapeutics · 2009Article
- Non-selective cation channels, transient receptor potential channels and ischemic stroke.Biochimica et biophysica acta · 2007Review
- (-)-Epigallocatechin-3-gallate induces contraction of the rat aorta by a calcium influx-dependent mechanism.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- Pharmacological profile of store-operated channels in cerebral arteriolar smooth muscle cells.British journal of pharmacology · 2003Article
- Nitric oxide co-ordinates the activities of the capacitative and non-capacitative Ca2+-entry pathways regulated by vasopressin.The Biochemical journal · 2003Article
- Characterization of G proteins involved in activation of nonselective cation channels by endothelin(B) receptor.British journal of pharmacology · 2002Article
- Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.British journal of pharmacology · 2001Article
- Rho-kinase inhibitors prevent agonist-induced vasospasm in human internal mammary artery.British journal of pharmacology · 2001Article
- Chlorpromazine inhibits store-operated calcium entry and subsequent noradrenaline secretion in PC12 cells.British journal of pharmacology · 2001Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have recently shown that endothelin-1 (ET-1) activates two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and store-operated Ca2+ channel (SOCC). These channels can be pharmacologically discriminated using Ca2+ channel blockers such as SK&F 96365 and LOE 908. Here we characterized Ca2+ entry channels involved in ET-1-induced contractions of rat thoracic aortic rings and increases in the intracellular free Ca2+ concentration ([Ca2+]i) of single smooth muscle cells using these blockers. LOE 908 or a blocker of voltage-operated Ca2+ channel nifedipine had no effect on the contractions and increases in [Ca2+]i induced by thapsigargin or ionomycin, whereas SK&F 96365 abolished them. The contractions and increases in [Ca2+]i induced by ET-1 depended on extracellular Ca2+ but were resistant to nifedipine. The responses to lower concentrations (< or =0.1 nM) of ET-1 were abolished by either SK&F 96365 or LOE 908. The responses to higher concentrations (> or = 1 nM) were abolished by SK&F 96365, but were partially resistant to LOE 908. SK&F 96365 inhibited the LOE 908-resistant contractions induced by higher concentrations of ET-1 with IC50 values similar to those for contractions induced by thapsigargin or ionomycin. These results show that the contractions and increases in [Ca2+]i of rat aortic smooth muscles at lower concentrations of ET-1 involve only one Ca2+ entry channel which is sensitive to SK&F 96365 and LOE 908 (NSCC-2), whereas those at higher concentrations of ET-1 involve another Ca2+ entry channel which is sensitive to SK&F 96365 but resistant to LOE 908 (SOCC) in addition to the former channel.
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