ArticleBritish journal of pharmacology1999
Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 86 citations in OpenAlex.
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- Development of Adaptive Immunity and Its Role in Lung Remodeling.Advances in experimental medicine and biology · 2023Article
- Functional and morphologic dysfunctions in the airways of rats submitted to an experimental model of obesity-exacerbated asthma.Scientific reports · 2022Article
- Exercise and Asthma.Advances in experimental medicine and biology · 2020Review
- The effect of alpha linolenic acid on tracheal responsiveness, lung inflammation, and immune markers in sensitized rats.Iranian journal of basic medical sciences · 2019Article
- Leukotriene receptors as potential therapeutic targets.The Journal of clinical investigation · 2018Review
- The Effects ofIranian journal of pharmaceutical research : IJPR · 2018Article
- The effect of hydro-ethanolic extract ofIranian journal of basic medical sciences · 2017Article
- The Effect ofFrontiers in pharmacology · 2017Article
- Mesenchymal stem cells regulate airway contractile tissue remodeling in murine experimental asthma.Allergy · 2014Article
- Does airway smooth muscle express an inflammatory phenotype in asthma?British journal of pharmacology · 2011Review
- Genetic influences on asthma susceptibility in the developing lung.American journal of respiratory cell and molecular biology · 2010Article
- Cell-based multiscale computational modeling of small molecule absorption and retention in the lungs.Pharmaceutical research · 2010Article
- Article
- Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma.Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
- Muscarinic receptor signaling in the pathophysiology of asthma and COPD.Respiratory research · 2006Review
- Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma.The Journal of clinical investigation · 2005Article
- Airway remodeling: lessons from animal models.Clinical reviews in allergy & immunology · 2004Review
- Factors controlling airway smooth muscle proliferation in asthma.Current allergy and asthma reports · 2004Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airway smooth muscle thickening is a characteristic feature of airway wall remodelling in chronic asthma. We have investigated the role of the leukotrienes in airway smooth muscle (ASM) and epithelial cell DNA synthesis and ASM thickening following repeated allergen exposure in Brown Norway rats sensitized to ovalbumin. There was a 3 fold increase in ASM cell DNA synthesis, as measured by percentage bromodeoxyuridine (BrdU) incorporation, in repeatedly ovalbumin-exposed (4.1%, 3.6-4.6; mean, 95% c.i.) compared to chronically saline-exposed rats (1.3%, 0.6-2.1; P<0.001). Treatment with a 5-lipoxygenase enzyme inhibitor (SB 210661, 10 mg kg(-1), p.o.) and a specific cysteinyl leukotriene (CysLT1) receptor antagonist, pranlukast (SB 205312, 30 mg kg(-1), p.o.), both attenuated ASM cell DNA synthesis. Treatment with a specific leukotriene B4 (BLT) receptor antagonist (SB 201146, 15 mg kg(-1), p.o.) had no effect. There was also a significant, 2 fold increase in the number of epithelial cells incorporating BrdU per unit length of basement membrane after repeated allergen exposure. This response was not inhibited by treatment with SB 210661, pranlukast or SB 201146. A significant increase in ASM thickness was identified following repeated allergen exposure and this response was attenuated significantly by SB 210661, pranlukast and SB 201146. Rats exposed to chronic allergen exhibited bronchial hyperresponsiveness to acetylcholine and had significant eosinophil recruitment into the lungs. Treatment with SB 210661, pranlukast or SB 201146 significantly attenuated eosinophil recruitment into the lungs, whilst having no significant effect on airway hyperresponsiveness. These data indicate that the cysteinyl leukotrienes are important mediators in allergen-induced ASM cell DNA synthesis in rats, while both LTB4 and cysteinyl leukotrienes contribute to ASM thickening and eosinophil recruitment following repeated allergen exposure.
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