ArticleNucleic acids research1999
Transcriptional pause, arrest and termination sites for RNA polymerase II in mammalian N- and c-myc genes.
Article in Nucleic acids research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Hantavirus L protein exhibits shutoff activity mediated by its N-terminal endonuclease domain.Scientific reports · 2026Article
- Basic mechanisms and kinetics of pause-interspersed transcript elongation.Nucleic acids research · 2021Review
- Regulatory mechanisms of incomplete huntingtin mRNA splicing.Nature communications · 2018Article
- RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing.Molecular cell · 2018Article
- Article
- A Two-Way Street: Regulatory Interplay between RNA Polymerase and Nascent RNA Structure.Trends in biochemical sciences · 2016Review
- TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene.Scientific reports · 2016Article
- Visualizing translocation dynamics and nascent transcript errors in paused RNA polymerases in vivo.Genome biology · 2015Article
- MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region.PloS one · 2015Article
- Intrinsic translocation barrier as an initial step in pausing by RNA polymerase II.Journal of molecular biology · 2013Article
- Article
- Genome-Wide Analysis of Nascent Transcription in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2011Article
- Transcriptional attenuation in colon carcinoma cells in response to butyrate.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Deletion of switch 3 results in an archaeal RNA polymerase that is defective in transcript elongation.The Journal of biological chemistry · 2010Article
- Rpb9 subunit controls transcription fidelity by delaying NTP sequestration in RNA polymerase II.The Journal of biological chemistry · 2009Article
- Glucocorticoid resistance in a multiple myeloma cell line is regulated by a transcription elongation block in the glucocorticoid receptor gene (NR3C1).British journal of haematology · 2009Article
- Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells.Journal of cellular physiology · 2009Article
- Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.BMC cancer · 2008Article
- Monitoring RNA transcription in real time by using surface plasmon resonance.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using either highly purified RNA polymerase II (pol II) elongation complexes assembled on oligo(dC)-tailed templates or promoter-initiated (extract-generated) pol II elongation complexes, the precise 3" ends of transcripts produced during transcription in vitro at several human c- and N- myc pause, arrest and termination sites were determined. Despite a low overall similarity between the entire c- and N- myc first exon sequences, many positions of pol II pausing, arrest or termination occurred within short regions of related sequence shared between the c- and N- myc templates. The c- and N- myc genes showed three general classes of sequence conservation near intrinsic pause, arrest or termination sites: (i) sites where arrest or termination occurred after the synthesis of runs of uridines (Us) preceding the transcript 3" end, (ii) sites downstream of potential RNA hairpins and (iii) sites after nucleotide addition following either a U or a C or following a combination of several pyrimidines near the transcript 3" end. The finding that regions of similarity occur near the sites of pol II pausing, arrest or termination suggests that the mechanism of c- and N- myc regulation at the level of transcript elongation may be similar and not divergent as previously proposed.
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