ArticleNucleic acids research1999
Optimization of alternate-strand triple helix formation at the 5"-TpA-3" and 5"-ApT-3" junctions.
Article in Nucleic acids research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- In vitro selection of oligonucleotides that bind double-stranded DNA in the presence of triplex-stabilizing agents.Nucleic acids research · 2010Article
- Design of a novel triple helix-forming oligodeoxyribonucleotide directed to the major promoter of the c-myc gene.Nucleic acids research · 2002Article
- Review
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4 authors.
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Abstract
Alternate-strand triple helix formation was optimized at the two junction steps, the 5"-TpA-3" and 5"-ApT-3" junctions. Footprint experiments, gel retardation assays and thermal denaturation measures on a sequence appropriately designed with two adjacent alternate-strand polypurine tracts points out that the addition of an adenine residue and the removal of one nucleotide should facilitate the crossing strands at the 5"-TpA-3" junction and at the 5"-ApT-3" junction, respectively. These results provide a 'switch code' for the construction of alternate-strand triple helix forming oligonucleotides which open new possibilities for extending the range of applications of antigene strategy.
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