ArticleMolecular and cellular biology1999
Involvement of DNA end-binding protein Ku in Ty element retrotransposition.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Recurrent Duplication and Diversification of a Vital DNA Repair Gene Family Across Drosophila.Molecular biology and evolution · 2024Article
- Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery.International journal of molecular sciences · 2021Review
- Nuku, a family of primate retrocopies derived from KU70.G3 (Bethesda, Md.) · 2021Article
- Review
- Transposable elements and G-quadruplexes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Guanine quadruplexes are formed by specific regions of human transposable elements.BMC genomics · 2014Article
- Host protein Ku70 binds and protects HIV-1 integrase from proteasomal degradation and is required for HIV replication.The Journal of biological chemistry · 2011Article
- Ancient and recent adaptive evolution of primate non-homologous end joining genes.PLoS genetics · 2010Article
- Ty1 integrase overexpression leads to integration of non-Ty1 DNA fragments into the genome of Saccharomyces cerevisiae.Molecular genetics and genomics : MGG · 2010Review
- Article
- Article
- Survey of repetitive sequences in Silene latifolia with respect to their distribution on sex chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.Molecular cell · 2007Article
- A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Ku80 participates in the targeting of retroviral transgenes to the chromatin of CHO cells.Journal of virology · 2007Article
- Host factors that control long terminal repeat retrotransposons in Saccharomyces cerevisiae: implications for regulation of mammalian retroviruses.Eukaryotic cell · 2007Review
- Endonuclease-independent insertion provides an alternative pathway for L1 retrotransposition in the human genome.Nucleic acids research · 2007Article
- Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- DNA damage and L1 retrotransposition.Journal of biomedicine & biotechnology · 2006Article
- Article
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2 authors.
Funding
Abstract
Saccharomyces cerevisiae Ty elements are retrotransposons whose life cycles are strikingly similar to those of retroviruses. They transpose via an RNA intermediate that is converted to linear double-stranded cDNA and then inserted into the host genome. Although Ty integration is mediated by the element-encoded integrase, it has been proposed that host factors are involved in this process. Here, we show that the DNA end-binding protein Ku, which functions in DNA double-strand break repair, potentiates retrotransposition. Specifically, by using a galactose-inducible Ty1 system, we found that in vivo, Ty1 retrotransposition rates were substantially reduced in the absence of Ku. In contrast, this phenotype was not observed with yeast strains containing mutations in other genes that are involved in DNA repair. We present evidence that Ku associates with Ty1 viruslike particles both in vitro and in vivo. These results provide an additional role for Ku and suggest that it might function in the life cycles of retroelements in other systems.
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