ArticleMolecular and cellular biology1999
Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 104 citations in OpenAlex.
- Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development.Cancers · 2018Review
- Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor.Biochemistry · 2017Article
- Article
- Focal adhesion kinase signaling is decreased 56 days following spinal cord injury in rat gastrocnemius.Spinal cord · 2016Article
- FAK and paxillin, two potential targets in pancreatic cancer.Oncotarget · 2016Review
- Integrins and integrin-related proteins in cardiac fibrosis.Journal of molecular and cellular cardiology · 2016Review
- Role of focal adhesion kinase in oocyte-follicle communication.Molecular reproduction and development · 2015Article
- Integrins and integrin-associated proteins in the cardiac myocyte.Circulation research · 2014Review
- Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes.PloS one · 2014Article
- Protein tyrosine kinase signaling in the mouse oocyte cortex during sperm-egg interactions and anaphase resumption.Molecular reproduction and development · 2013Article
- Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.The Journal of biological chemistry · 2012Article
- Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling.Cell host & microbe · 2012Article
- FRNK overexpression limits the depth and frequency of vascular smooth muscle cell invasion in a three-dimensional fibrin matrix.Journal of cellular physiology · 2010Article
- Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts.Experimental cell research · 2010Article
- Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).The Journal of biological chemistry · 2010Article
- Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration.Cardiovascular research · 2010Article
- Progress in researches about focal adhesion kinase in gastrointestinal tract.World journal of gastroenterology · 2009Review
- Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth.Circulation research · 2009Article
- Low intensity shear stress increases endothelial ELR+ CXC chemokine production via a focal adhesion kinase-p38{beta} MAPK-NF-{kappa}B pathway.The Journal of biological chemistry · 2009Article
- TGF-beta1 modulates focal adhesion kinase expression in rat intestinal epithelial IEC-6 cells via stimulatory and inhibitory Smad binding elements.Biochimica et biophysica acta · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Focal adhesion kinase (FAK) has been implicated in cellular processes that control cell adhesion, migration, cell cycle progression, and apoptosis. FRNK (FAK-related nonkinase) is the autonomously expressed, noncatalytic C-terminal portion of FAK. When ectopically expressed in cells, FRNK has been shown to act as a negative regulator of FAK activity, inhibiting cell spreading, migration, and cell cycle progression. The mechanisms that regulate FRNK expression during embryonic development and the functional role of FRNK in normal cell homeostasis remain poorly understood. Herein we show that FRNK expression in chicken cells is directed by an alternative promoter residing within an intron of FAK, positioned 3' of the exon encoding sequences for the catalytic domain and 5' of the exon encoding sequences for the C-terminal domain of FAK (e.g., FRNK). Using probes specific for FRNK, we show that FRNK expression occurs early in chicken embryogenesis, being readily detected at day 3, 6, or 9. Late in embryogenesis, at day 18, FRNK is expressed in a tissue-specific manner, predominately in lung and intestine cells. Western blot analysis of mouse tissues with a FAK-specific antibody revealed the expression of FRNK in the mouse lung. Reverse transcriptase PCR analysis of mouse lung RNA revealed the presence of spliced FRNK mRNAs containing 5' untranslated sequences derived from a positionally conserved exon present in the mouse genome. FAK is the first example of a tyrosine kinase regulated by a domain under the control of an alternative intronic promoter. It is also the first example of a focal adhesion-associated protein regulated by such a mechanism and thus represents a novel means for the modulation of cell adhesion signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.