ArticleMolecular and cellular biology1999
Functional analysis of the SIN3-histone deacetylase RPD3-RbAp48-histone H4 connection in the Xenopus oocyte.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- RebL1 is required for macronuclear structure stability and gametogenesis inMarine life science & technology · 2024Article
- Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review).International journal of molecular medicine · 2024Review
- Identification of miR-6794-3p as a suppressor in pancreatic cancer metastasis.International journal of biological sciences · 2024Article
- RBBP4 promotes colon cancer malignant progressionWorld journal of gastroenterology · 2020Article
- Engaging chromatin: PRC2 structure meets function.British journal of cancer · 2020Review
- The structure of the core NuRD repression complex provides insights into its interaction with chromatin.eLife · 2016Article
- Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins.Cell reports · 2016Article
- Genome-Wide Analysis of Gene Regulatory Networks of the FVE-HDA6-FLD Complex in Arabidopsis.Frontiers in plant science · 2016Article
- Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- RBBP4 regulates histone deacetylation and bipolar spindle assembly during oocyte maturation in the mouse.Biology of reproduction · 2015Article
- Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex.Genes & development · 2014Article
- Knockdown of RBBP7 unveils a requirement of histone deacetylation for CPC function in mouse oocytes.Cell cycle (Georgetown, Tex.) · 2014Article
- Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin.Genes & development · 2013Article
- Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48.Science translational medicine · 2013Article
- Polycomb group gene OsFIE2 regulates rice (Oryza sativa) seed development and grain filling via a mechanism distinct from Arabidopsis.PLoS genetics · 2013Article
- Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions.The Journal of biological chemistry · 2010Article
- Characterization of the expression pattern of the PRC2 core subunit Suz12 during embryonic development of Xenopus laevis.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development.The international journal of biochemistry & cell biology · 2009Review
- Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46.Structure (London, England : 1993) · 2008Article
- Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD.Antioxidants & redox signaling · 2008Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the protein associations and enzymatic requirements for the Xenopus histone deacetylase catalytic subunit RPD3 to direct transcriptional repression in Xenopus oocytes. Endogenous Xenopus RPD3 is present in nuclear and cytoplasmic pools, whereas RbAp48 and SIN3 are predominantly nuclear. We cloned Xenopus RbAp48 and SIN3 and show that expression of RPD3, but not RbAp48 or SIN3, leads to an increase in nuclear and cytoplasmic histone deacetylase activity and transcriptional repression of the TRbetaA promoter. This repression requires deacetylase activity and nuclear import of RPD3 mediated by a carboxy-terminal nuclear localization signal. Exogenous RPD3 is not incorporated into previously described oocyte deacetylase and ATPase complexes but cofractionates with a component of the endogenous RbAp48 in the oocyte nucleus. We show that RPD3 associates with RbAp48 through N- and C-terminal contacts and that RbAp48 also interacts with SIN3. Xenopus RbAp48 selectively binds to the segment of the N-terminal tail immediately proximal to the histone fold domain of histone H4 in vivo. Exogenous RPD3 may be targeted to histones through interaction with endogenous RbAp48 to direct transcriptional repression of the Xenopus TRbetaA promoter in the oocyte nucleus. However, the exogenous RPD3 deacetylase functions to repress transcription in the absence of a requirement for association with SIN3 or other targeted corepressors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.